DNA模式识别受体研究进展  

Progress on DNA Innate Immune Recognition Receptors

作　　者：陈青[1] 朱鸿飞[2] 郭晓宇[2] 

机构地区：[1]北京农学院农业部都市农业(北方)重点实验室,北京102206 [2]中国农业科学院北京畜牧兽医研究所,北京100193

出　　处：《中国生物工程杂志》2016年第5期112-117,共6页China Biotechnology

基　　金：国家自然科学基金(31402232);北京农学院优秀青年教师培育计划(BNRC&YX201404)资助项目

摘　　要：固有免疫系统利用模式识别受体识别病原相关分子模式。近期研究发现,外源DNA能够被宿主细胞中多种DNA受体识别,激活多种信号通路,上调Ⅰ型干扰素和促炎性细胞因子的表达。基于DNA的免疫识别在激活宿主抗感染免疫过程中起重要作用,因此仅对现已报道的DNA受体进行概述,同时对DNA的免疫识别与自身免疫病之间的关系进行探讨。The innate immune system deploys pattern recognition receptor（ PRR） to detect pathogenassociated molecular pattern（ PAMP）. Microbial DNA could be recognized by various host DNA sensors that are either membrane-bound or located in the cytosol, and stimulate the production of type I interferons and proinflammatory cytokines. DNA-stimulated innate immune activation plays an important role in antimicrobial response as well as certain autoimmune diseases. The recent progress in identification of novel DNA sensors in host cells,and the related signaling pathways that lead to the innate immune activation were summarized.

关 键 词：固有免疫 模式识别 DNA受体 Ⅰ型干扰素 促炎性细胞因子 

分 类 号：Q789[生物学—分子生物学]