胰岛素泵治疗2型糖尿病的基础率大剂量特点  

The feature of basal rate and bolus doses of insulin pump in treatment in the type 2 diabetes mellitus

作　　者：洛佩[1] 龚敏[1] 牛晶晶[1] 陈丽华[1] 贺艳菊[1] 陈隶华 周里钢[1] 

机构地区：[1]复旦大学附属浦东医院,上海201399

出　　处：《热带医学杂志》2016年第5期608-611,共4页Journal of Tropical Medicine

基　　金：国家自然科学基金面上项目(81370932);浦东新区领先人才项目(PWR12014-06);美国MERCK IISP基金(#40313 and#40309)

摘　　要：目的初步探讨胰岛素泵治疗空腹血糖升高或餐后血糖升高为主的2型糖尿病(T2DM)的基础率及大剂量的特点。方法 112例T2DM,根据手指血糖分为空腹血糖高组(A组)和餐后血糖高组(B组),胰岛素泵(CSII)治疗8 d,比较血糖及胰岛素剂量变化,及2组间异同。结果治疗8 d,A、B组每天8次指血糖均显著降低(P<0.01)。A、B组基础率,每天的基础总量(TBD),3餐前剂量,以及进餐大剂量总和(DD)显著增加(P<0.01)。A、B组8 d TBD、DD及TBD/DD差异均无统计学意义(P>0.05)。结论对于空腹血糖升高或餐后血糖升高为主的病人,基础用量和进餐用量的分布无差异。Objective To investigate the feature of basal rate and bolus doses of insulin pump in the treatment in the patients with the type 2 diabetes mellitus（T2DM） with abnormal fasting plasma glucose（FPG） or postprandial plasma glucose（2h PG）. Methods A total of 112 cases of with T2 DM were assigned to Group A with abnormal FPG and Group B with abnormal 2h PG. They were treated by continuous subcutaneous insulin infusion（CSII） with insulin pump for 8days, and then the changes in blood glucose and dosage of insulin were compared between the two groups. Results During these 8 days, eight times of finger glucose were measured per day, and FPG and 2h PG in both group A and group B were reduced significantly（P〈0.01）. The basal dosage of insulin per day, total basal dosage（TBD）, 3 bolus dosage before meal, total dining dose（DD） in group A and B were significantly increased（P〈0.01）. No significant differences were observed on TBD, DD and TBD / DD between group A and B for 8 days（P 〉0.05）. Conclusion The pattern of using per day based on dosage and before a meal was not different between T2 DM patients characterized with higher FPG and higher 2hPG.

关 键 词：2型糖尿病 胰岛素泵 基础率 大剂量 

分 类 号：R587.1[医药卫生—内分泌]