输血相关性急性肺损伤回顾性调查分析——附2例报告  

Retrospective review on two cases of transfusion related acute lung injury

作　　者：杜红梅 李淑红 吴松远[2] 

机构地区：[1]平顶山市中心血站,河南平顶山467000 [2]平煤集团总医院

出　　处：《中国输血杂志》2016年第4期395-397,共3页Chinese Journal of Blood Transfusion

摘　　要：目的通过对2例输血相关性肺损伤(transfusion-related actute lung injury,TRALI)的调查并分析其发病因素,为TRALI的预防提供参考。方法回顾性调查2名抢救性患者在输血治疗过程中发生TRALI反应的临床病历和献血者的相关资料,分析发生TRALI的危险因素。结果 2名创伤性手术患者均在输血治疗过程中输入了富含血浆的血液成分而导致TRALI发生,虽经积极抢救,1例治愈,1例死亡。2名TRALI患者所输血液成分来自4名供血者,其中2人为经产妇,另2人均为男性献血者,追踪4名供血者以往的受血者,无1人发生TRALI反应。结论患者输血治疗时有大的创伤性因素存在,是发生TRALI的危险因素;富含血浆是引起发生TRALI的直接诱因,存在TRALI高危因素的患者应尽量减少血浆制品的输入以预防TRALI的发生。Objective To analyze the risk factors in two cases of blood transfusion-related acute lung injury（ TRALI）,and to provide reference for the prevention of TRALI. Methods The clinical data on the two cases of TRALI were retrospectively analyzed. The pathogenesis,diagnosis and treatment of TRALI were reviewed. Results The two cases of TRALI patients both were infused with transfused blood containing high amount of plasma during traumatic surgery,of which,one patient was cured,the other patient died. The blood infused in the two cases of TRALI patients came from four blood donor：two were multipara female blood donors,other two were male blood donors. A follow-up on the past recipients from these four blood donor has found no cases of TRALI reaction. Conclusion Blood transfusions carry major complications,including trauma,which confers the major risk in developing TRALI. Blood products that are rich in plasma constitute the direct cause of TRALI in blood transfusion patients. Patients with high risk factors in developing TRALI should minimize infusion in order to prevent the occurrence of TRALI.

关 键 词：TRALI 创伤性 输血 

分 类 号：R457.1[医药卫生—治疗学]