阿托伐他汀预处理对急性冠脉综合征患者冠脉介入术的疗效  

Therapeutic effect of atorvastatin pretreatment foe coronary intervention in patients with non-ST segment elevation acute coronary syndrome

作　　者：赵献明[1] 许春平[1] 曾波[1] 黎素军[1] 梁伟东[1] 

机构地区：[1]广西南宁市第一人民医院心内科,广西南宁530022

出　　处：《心血管康复医学杂志》2016年第3期283-285,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

基　　金：南宁市科学研究与技术开发计划项目(ZC200802C)~~

摘　　要：目的:研究非ST抬高急性冠脉综合征(NSTE-ACS)患者冠脉介入术前预处理使用阿托伐他汀钙片的疗效。方法:选择82例住院的NSTE-ACS患者,随机均分为常规治疗组(41例,术前未服用阿托伐他汀钙)和阿托伐他汀钙预处理组(预处理组,41例,PCI前24h内服用80mg的阿托伐他汀钙片),术后分别检测血清心肌损伤标记物心肌肌钙蛋白T(cTnT)、肌酸激酶同工酶(CK-MB)和脑钠肽(BNP)水平,统计比较两组术后30d和60d的主要心血管不良事件发生率。结果:冠脉介入治疗后12h,与常规治疗组比较,预处理组的血清cTnT[(1.74±0.32)μg/L比(1.06±0.43)μg/L]和CK-MB[(15.7±6.2)mmol/L比(12.4±7.3)mmol/L]水平显著降低(P<0.01,P<0.05);但血清BNP水平无统计学差异(P>0.05),且冠脉介入治疗后的30d和60d,两组间主要心血管不良事件发生率无显著性差异(P均>0.05)。结论:预处理应用阿托伐他汀钙片可减轻非ST段抬高急性冠脉综合征患者冠脉介入术的心肌损伤。Objective： To study therapeutic effect of atorvastatin calcium tablet pretreatmentonary intervention （PCI） in patients with non-ST elevation acute coronary syndrome （NSTE-ACS）. Methods： A total of 82 NSTE-ACS patients hospitalized were selected and randomly and equally divided into rou group （n=41,didn＇t receive atorvastatin calcium before PCI） and atorvastatin calcium pretreatment group （p retreatment group,n= 41, received atorvastatin calcium tablet within 24h before PCI） . Serum levels of cardiac troponin T （cTnT）,creatine kinase isoenzyme MB （CK - MB） and brain natriuretic peptide （BNP） were measured andcompared between two groups after PCI,incidence rates of postoperative 30d and 60d major cardiovascular adverse events （MACE） were statistically analyzed. Results： Compared with routine treatment group on 12h after PCI,there were significant reductions in serum levels of cTnT [ （1. 74 ± 0. 3 2 ）μg /L vs . （1. 06 ± 0. 4 3 ）μg/L] and CK - MB[（15.7±6.2）mmol/L vs.（12.4±7.3）mmol/L]inpre treatment group,P 〈0 .0 1,P〈0 .0 5 ; th e rew a s n o significant difference in serum BNP level between two groups,P 〉 0 . 05. There were no significant cidence rates of postoperative 30d and 60d MACE between two groups,P〉0. 05 both. Conclusion： Pretreatment application of atorvastatin calcium tablet can relieve myocardial injury after PCI in NSTE-ACS patients.

关 键 词：急性冠状动脉综合征 血管成形术 气囊 冠状动脉 阿托伐他汀 

分 类 号：R541.4[医药卫生—心血管疾病]