评估光动力血管损伤的光学监测技术  

Optical Monitoring Techniques for Assessing Vascular Damage of Vascular Targeted Photodynamic Therapy

作　　者：林黎升[1] 陈德福[2] 顾瑛[2] 谢树森[1] 李步洪[1] 

机构地区：[1]福建师范大学医学光电科学与技术教育部重点实验室福建省光子技术重点实验室,福建福州350007 [2]中国人民解放军总医院激光医学科,北京100853

出　　处：《激光生物学报》2016年第2期97-106,共10页Acta Laser Biology Sinica

基　　金：国家自然科学基金项目(61520106015;61275216);国家卫计委科学研究基金(WKJ-FJ-30);福建省自然科学基金项目(2014J07008);福建省教育厅科技项目(JA15104)

摘　　要：血管靶向光动力疗法(Vascular targeted photodynamic therapy,V-PDT)已成为临床治疗鲜红斑痣和老年黄斑变性等血管性疾病的重要方法。V-PDT通过主动或被动血管靶向的作用机制诱发系列生物响应以封闭病变血管。本文评述了V-PDT的作用机制和血管生物学响应,重点讨论了用于评估V-PDT中血管损伤的光谱与成像技术,并分析了这些技术的优点和局限性。最后展望了用于评估V-PDT血管损伤的光学技术发展及其应用前景。Vascular targeted photodynamic therapy( V-PDT) is widely utilized for the clinical treatments for port wine stain and age-related macular degeneration. Serial vascular responses through active or passive targeted mechanisms can be induced for the closure of blood vessels after V-PDT. In this review,the fundamental mechanisms of vascular responses during V-PDT will be illustrated. Furthermore,the current available optical techniques for assessing the vascular damage after V-PDT are summarized,and the advantages and limitations of each optical technique will be discussed.This review concludes with a discussion on the future demands of optical monitoring techniques for assessing vascular damage during V-PDT.

关 键 词：光动力学疗法 生物响应 血管损伤 无损 光学监测技术 

分 类 号：R318.51[医药卫生—生物医学工程]