气相色谱法测定伊潘立酮起始原料中1,2-二氯乙烷  

Determination of 1,2-dichloroethane in Iloperidone Starting Material by Gas Chromatography

作　　者：黄凤芸 靳朝东[2] 陈晓雨[1] 李银峰[2] 

机构地区：[1]天津中医药大学,天津300193 [2]天津药物研究院分析测试中心,天津300193

出　　处：《现代仪器与医疗》2016年第3期67-69,共3页Modern Instruments & Medical Treatment

摘　　要：目的：建立伊潘立酮起始原料中1,2-二氯乙烷残留溶剂的测定方法。方法：采用顶空进样毛细管气相色谱法。色谱柱：Agilent DB-624毛细管柱（30m×0.53mm×3.0μm）;程序升温;检测器：电子捕获检测器（ECD）,温度：250℃;恒压：2.5psi;载气为高纯氮气。结果：1,2-二氯乙烷在0.55-2.00μg/mL浓度范围内线性关系良好（r=0.9999）,平均回收率为101.1%;定量限为2.75ppm;检测限为0.75ppm。结论：建立的方法操作简便、灵敏度高,结果准确,可有效检测伊潘立酮起始原料中一类溶剂1,2-二氯乙烷的残留量。Objective： To establish the method for the determination of 1,2-dichloroethane in iloperidonestartingmaterial. Methods： Headspace capillary gas chromatography. The determination was performed on Agilent DB-624capillary column by temperature programming.The temperature of electron capture detector was set at 250℃,steadypressure was set at 2.5psiand high purity N2was used as carrier gas. Results： The good linear range of 1,2-dichloroethaneorganic solvent had been obtained at 0.55μg / ml - 2.00μg / ml concentration range（r=0.9999）with average recoveryof 101.1%.The limit of quantification was2.75ppm. The limit of detection was0.75ppm. Conclusion： The establishedmethod is simple, sensitive, accurate,and it can be effectively used in the determination of 1,2-dichloroethaneiniloperidonestarting material.

关 键 词：伊潘立酮起始原料 1 2-二氯乙烷 顶空气相色谱法 

分 类 号：O657[理学—分析化学]