^(11)C-蛋氨酸及^(11)C-胆碱联合^(18)F-氟代脱氧葡萄糖在胶质瘤诊断中的价值  

The value of ^(11)C-MET,^(11)C-CHO associated with ^(18)F-FDG in diagnosing patients with glioma

作　　者：王治国[1] 左峰[1] 张国旭[1] 张宗鹏[1] 石庆学[1] 吴锐先[1] 郭佳[1] 

机构地区：[1]沈阳军区总医院核医学科,辽宁沈阳110840

出　　处：《中国医学装备》2016年第6期60-63,共4页China Medical Equipment

摘　　要：目的:探讨^(18)F-氟代脱氧葡萄糖(^(18)F-FDG)、^(11)C-蛋氨酸(^(11)C-MET)和^(11)C-胆碱(^(11)C-CHO)PET/CT对脑胶质瘤的临床诊断价值。方法:选取经病理证实的33例胶质瘤患者,使用FXFDG、FXC合成器分别对各显像剂进行合成与质量控制;对脑胶质瘤患者行^(18)F-FDG、^(11)C-MET和^(11)C-CHO PET/CT单独或联合显像,分析3种显像剂联合诊断的灵敏度、特异度和准确率。结果:3种显像剂联合使用进行胶质瘤诊断,其灵敏度、特异度和准确率分别为96%、100%和97%。结论:3种显像剂均为常见正电子显像剂,合成方便,联合使用有利于脑胶质瘤诊断准确性的提高。Objective：To investigate the diagnostic potential value of18F-fluoro-deoxy-glucose （18F-FDG）,11C-methionine （11C-MET） and11C-choline （11C-CHO） PET/CT for glioma grading. Methods： The tracer was synthesized by FX-FDG and FX-C synthesizer of GE. 33 cases of suspected patients from September 2011 to September 2013 were chosen for individual and combined imaging, and preliminary data was analyzed.Results： The sensitivity, specificity and accuracy are increased to 96%, 100% and 97% with combined using of the three imaging agent for glioma diagnosis.Conclusion： The accuracy of glioma diagnosis can be improved by combined using18F-FDG,11C-MET and11C-CHO.

关 键 词：PET/CT 显像剂 氟代脱氧葡萄糖 胆碱 蛋氨酸 胶质瘤 

分 类 号：R817.4[医药卫生—影像医学与核医学]