甲状腺结节危险因素的meta分析  

Meta-analysis on risk factors of thyroid nodules

作　　者：杜丹[1] 李阳桦 陈艳伟[1] 李爽[1] 刘博[1] 王全意[1] 黎新宇[1] 

机构地区：[1]北京市疾病预防控制中心传染病地方病控制所,北京100013

出　　处：《职业与健康》2016年第8期1034-1037,共4页Occupation and Health

基　　金：北京市自然科学基金项目(7123218)

摘　　要：目的综合评价甲状腺结节发生的危险因素。方法应用meta分析的方法对国内有关甲状腺结节发病危险因素的研究结果进行定量综合分析;运用Revman 5.0进行异质性检验以及合并OR值和95%可信区间的计算。结果性别、2型糖尿病、超重/肥胖与甲状腺结节关系的OR值分别为2.02(1.73,2.37)、2.70(1.00,7.29)、2.34(1.40,3.90),合并结果稳定性较好,可认为是甲状腺结节发生的危险因素;碘缺乏、碘过量与甲状腺结节关系的OR值分别为1.42(0.84,2.41)、1.76(0.88,3.53),尚不能确定碘缺乏、碘过量与甲状腺结节的关系。结论现有的有限证据表明,性别(女性)、2型糖尿病、超重/肥胖是甲状腺结节发生的危险因素,碘缺乏和碘过量是否增加甲状腺结节的发病尚无足够的证据。[Objective]To evaluate the risk factors of thyroid nodules. [Methods]A comprehensive quantitative analysis of the domestic research results about the risk factors of thyroid nodules was conducted by the Meta analysis method. Rev Man 5.0 was used to perform the heterogeneity test and calculate the pooled OR value and 95% confidence interval.[Results]OR value of gender,type 2 diabetes and overweight/obesity was respectively 2.02（1.73,2.37）,2.70（1.00,7.29） and 2.34（1.40,3.90）,and the combined result was stable,which were regarded as the risk factor of thyroid nodules. OR value of iodine deficiency and excessive iodine was 1.42（0.84,2.41） and 1.76（0.88,3.53） respectively,which indicated that the relationship between these factors and thyroid nodules have not been determined.[Conclusion]The limited available evidences suggest that gender（female）,type 2diabetes and overweight/obesity are the risk factors of thyroid nodules. There is not enough evidence to prove the iodine deficiency and excessive iodine can increase the incidence of thyroid nodule.

关 键 词：甲状腺结节 危险因素 META分析 

分 类 号：R181.3[医药卫生—流行病学]