富亮氨酸胶质瘤失活1蛋白抗体脑炎的病理特征及临床分析(附1例案例报道)  

A Case Report of Leucine-rich Glioma Inactivated 1 Protein Antibody Associated Autoimmune Encephalitis and Literature Review

作　　者：刘勇[1,2] 赵代弟 张敏[1] 沈金金[1] 张巍[1] 李柱一[1] 

机构地区：[1]第四军医大学唐都医院神经内科,陕西西安710062 [2]靖边县人民医院,陕西榆林718500

出　　处：《现代生物医学进展》2016年第15期2885-2888,共4页Progress in Modern Biomedicine

基　　金：国家自然科学青年基金项目(81301069)

摘　　要：目的:探索富亮氨酸胶质瘤失活1蛋白(LGI1)抗体相关自身免疫性脑炎的临床特点及治疗。方法:报道l例LG I1抗体阳性相关自身免疫性脑炎的临床资料,并结合相关文献讨论该病的临床病理特点。结果:老年男性,亚急性起病,反复多次发作并进行性加重,以近记忆下降、癫痫、认知和睡眠障碍为主要表现;头颅MRI示脑萎缩;LGI1抗体阳性。结论:本病患者具有认知功能、睡眠障碍及癫痫等,血清和脑脊液中抗LGI1抗体阳性,但无低钠血症,头颅影像学检查正常;急性发作期给予免疫抑制剂治疗后可获良好效果。Objective： To explore the clinical feature and therapy of leucine-rich glioma inactivated 1 protein antibody associated autoimmune encephalitis（Ant i-LGI1 AE）. Methods： The clinical data of 1 case of patient with positive Anti-LGI1 antibody positive patient was reported, and the clinical features of Ant i-LGI1 AE was summarized with. Results： The patient is 71 years old who was admitted to the hospital due to the subacute symptoms of memory impairment, epilepsy as well as sleep disorder. MRI examination showed brain atrophy; and antibody against LGI1 in blood and cerebrospinal fluid was positive. Conclusions： Anti-LGI1 antibody positive encephalitis patients usually had cognitive impairment, sleep disorder, epilepsy, serum and positive CSF LG I1 antibody. In addition, patients often had no hyponatremia, and their cranial imaging examination showed normal. The patient＇s clinical symptoms was improved after receiving immunosuppressive treatment.

关 键 词：自身免疫性脑炎 LGI1抗体 癫痫 

分 类 号：R392[医药卫生—免疫学] R741.02[医药卫生—基础医学]