利伐沙班联合血塞通在预防老年髋部术后深静脉血栓形成中的疗效及对血液高凝状态的影响  

Effect of Rivaroxaban Combined with Xuesaitong in Prevention of Deep Venous Thrombosis after Hip surgery in Elderly Patients and Its Influence on Blood Hypercoagulability

作　　者：王国胜[1] 续斌[1] 高健[1] 曹明宇[1] 沈志敏[1] 

机构地区：[1]新疆医科大学第六附属医院关节外科,新疆乌鲁木齐830002

出　　处：《现代生物医学进展》2016年第15期2924-2927,共4页Progress in Modern Biomedicine

摘　　要：目的:探究利伐沙班联合血塞通在预防老年髋部术后深静脉血栓(DVT)形成中的疗效及对血液高凝状态的影响。方法:收集2012年9月-2015年10月期间我院下肢骨折行手术治疗患者118例为研究对象,采用随机数字法将其分为观察组(60例)和对照组(58例),对照组患者给予血塞通治疗,观察组患者在对照组基础上给予利伐沙班联合治疗,观察并比较两组患者治疗前后血液炎性指标、流变学指标及DVT的发生率。结果:观察组患者术后DVT发生率为11.67%,显著低于对照组的44.83%,差异具有统计学意义(P<0.05);治疗后两组患者C反应蛋白(CRP)、同型半胱氨酸及二聚体(D-D)水平较治疗前均出现显著下降(P<0.05),且观察组CRP、同型半胱氨酸及D-D水平均低于对照组,差异均有统计学意义(P<0.05);治疗后两组患者全血黏度、红细胞压积、纤维蛋白原水平较治疗前均出现显著下降(P<0.05),且观察组全血黏度、红细胞压积、纤维蛋白原水平均低于对照组,差异均有统计学意义(P<0.05)。结论:利伐沙班联合血塞通在预防老年髋部术后DVT形成中疗效显著,可显著降低术后患者DVT的发生率,改善血液高凝状态,具有十分重要的临床价值。Objective： To explore the effect of rivaroxaban combined with Xuesaitong in the prevention of deep venous thrombosis（DVT） after hip surgery in elderly patients and its influence on blood hypercoagulability. Methods： 118 cases of patients with lower limb fracture and were treated in our hospital from September 2012 to October 2015 were selected as research object,which were divided into observation group（60 patients） and control group（58 patients） by random number table method, Patients in control group were treated with Xuesaitong, and the patients in observation group were treated with rivaroxaban on the basis of control group, observed and compared the blood inflammatory indexes, rheological indexes and the incidence of DVT between two groups before and after treatment.Re sults： The incidence rate of DVT of patients in observation group after treatment was 11.67%, which was significantly lower than44.83% of control group, the difference was statistically significant（P〈0.05）; The levels of C-reactive protein（CRP）, homocysteine and D-Dimer（D-D）in both groups after treatment were significant lower than before treatment（P〈0.05）, and the levels of CRP, homocysteine and D-D of patients in observation group was significant lower than that of control group, the difference was statistically significant（P〈0.05）; The levels of whole blood viscosity, red blood cell volume, fibrinogen in both groups after treatment were significant lower than before treatment（P〈0.05）, and the levels of whole blood viscosity, red blood cell volume, fibrinogen in observation group was significant lower than that of control group（P〈0.05）. Conclusion： The effect of rivaroxaban combined with Xuesaitong in the prevention of deep venous thrombosis after hip surgery in elderly patients has significant effect, which is able to significantly reduce the incidence of postoperative patients with DVT, improve the blood hypercoagulability, and has a very important clinical value.

关 键 词：深静脉血栓 利伐沙班 血塞通 高凝状态 疗效 

分 类 号：R687[医药卫生—骨科学] R684.32[医药卫生—外科学]