慢性应激动脉粥样硬化动物模型和应激与AS的发生研究进展  

Animal Models of Atherosclerosis and Progress of Atherosclerosis Formation Caused by Long-Term Chronic Stress

作　　者：陈铭泰[1] 黄若兰[2] 富文俊[3] 王玲[2] 欧莉君[1] 张忠[1] 

机构地区：[1]广州中医药大学深圳临床医学院心血管科,广东深圳518000 [2]广州中医药大学深圳临床医学院重症医学科,广东深圳518000 [3]广州中医药大学基础医学院,广东广州510000

出　　处：《现代生物医学进展》2016年第15期2995-3000,共6页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81573922);广东省中医药局建设中医药强省科研课题项目(20151076);广东省科学技术厅-广东省中医药科学院联合科研项目(2014A020221002)

摘　　要：动脉粥样硬化(Atherosclerosis,AS)是缺血性心脑血管病的主要病理基础,环境、遗传等多因素共同影响下都能促进AS的形成与发展,越来越多研究表明慢性应激对于AS形成起到关键的作用,慢性应激可通过过度激活交感神经系统、肾素-血管紧张素系统与下丘脑-垂体-肾上腺皮质轴促进AS的形成,并且与Toll样受体、肿瘤坏死因子α、白细胞介素-6、脂联素等因素有密切联系。在研究慢性应激与AS发生的模型中,目前Apo E-/-小鼠、SD大鼠、Wistar大鼠等啮齿类动物仍然是主要模型,灵长类动物模型研究虽然更具有临床意义,但由于其成本、数量等因素限制了广泛使用。本文主要就慢性应激与AS的动物模型研究、慢性应激促进AS发生发展的相关机制进行综述。Atherosclerosis is the main pathological basis of ischemic cardio-cerebrovascular disease. Both environmental and genetic factors could lead to atherosclerosis formation. More and more evidences indicate that long-term chronic stress play crucial role in the formation and development of atherosclerosis. Excessive activation of sympathetic nervous system, renin- angiotensin system and hypothalamus-pituitary-adrenal cortex axis caused by long-term chronic stress, together with toll-like receptors, tumor necrosis factor α, interleukin-6 and adiponectin were the dominating reasons of atherosclerosis formation. At present, Apo E-/- mice, SD and Wistar rats are still the dominant models of atherosclerosis. Higher-cost and less number are major limitations of primate animal models, although they have more clinical superiority. This article discusses the potential mechanisms of long-term chronic stress promoting atherosclerosis formation, as well as the animal models with atherosclerosis influenced by long-term chronic stress.

关 键 词：慢性应激 动脉粥样硬化 动物模型 机制 

分 类 号：Q95-3[生物学—动物学] R543.5[医药卫生—心血管疾病]