栽培尼泊尔菊三七中的木脂素类化合物  

Lignans from cultivated Gynuranepalensis

作　　者：张志辉[1] 陆瑶[1] 邓安珺[1] 马林[1] 吴丰[1] 李志宏[1] 秦海林[1] 

机构地区：[1]中国医学科学院北京协和医学院药物研究所天然药物活性物质与功能国家重点实验室,北京100050

出　　处：《中国中药杂志》2016年第8期1456-1460,共5页China Journal of Chinese Materia Medica

摘　　要：采用溶剂提取、萃取粗分离、硅胶和Sephadex LH-20凝胶柱色谱以及制备HPLC等纯化技术,从采自北京郊区的尼泊尔菊三七栽培品中分离得到4个化合物,通过波谱分析并参考文献数据鉴定其结构分别为7S,8R-9＇-O-乙基-去氢双松柏醇-9-乙酸酯（1）、9＇-O-乙基-去氢双松柏醇（2）、去氢双松柏醇-9,9＇-二乙酸酯（3）和（＋）-梣皮树脂醇（4）。1为新的2,3-二氢苯并呋喃-8,3＇-新木脂素型化合物,2~4均为首次从尼泊尔菊三七中分离得到的木脂素类化合物。对4个化合物在DMSO-d6溶剂中的^1H-和^13C-NMR数据进行了全归属。Taking application of some isolation and purification technologies,including solvent extraction,rude solvent isolation,column chromatographies on silica gel and Sephadex LH-20,and preparative HPLC,4 compounds were obtained from Gynuranepalensiscultivated in a suburban area of Beijing. Their structures were identified by spectroscopic methods in conjunction with comparison of the NMR data with literature values as 7S,8R-9＇-O-ethyl-dehydrodiconiferyl-9-acetate（ 1）,9＇-O-ethyl-dehydrodiconiferyl alcohol（ 2）,dehydrodiconiferyl-9,9＇-diacetate（ 3）,and（ ＋）-medioresinol（ 4）,respectively. 1 is a new 2,3-dihydrobenzofuran-8,3＇-neolignane type compound,and 2-4 were isolated from G. nepalensis for the first time. The complete assignment of the ^1H-and ^13C-NMR spectroscopic data of the four compounds recorded in DMSO-d6 was achieved.

关 键 词：尼泊尔菊三七 菊科 木脂素 7S 8R-9'-O-乙基-去氢双松柏醇-9-乙酸酯 结构鉴定 

分 类 号：R284.1[医药卫生—中药学]