尼莫地平控释片辅助治疗海洛因戒断综合征  

ADJUVANT THERAPY OF NIMODIPINE CONTROLLED-RELEASE TABLETS FOR HEROIN WITHDRAWAL SYNDROME

作　　者：苏木金[1] 谭国生[1] 梁剑芳[1] 王爱兰[1] 王以秀[1] 

机构地区：[1]中国人民解放军广州疗养院,广州510515

出　　处：《中国药物依赖性杂志》2002年第3期204-205,219,共3页Chinese Journal of Drug Dependence

摘　　要：目的··:观察钙拮抗剂尼莫地平控释片对海洛因戒断综合征的辅助治疗作用。方法··:治疗组30例 ,采用美沙酮、丁丙诺啡梯度替代递减法治疗 ,同时口服尼莫地平控释片60mg,每天2次。对照组单纯使用美沙酮、丁丙诺啡梯度替代递减法治疗 ,10d为一疗程。结果··:治疗期间治疗组戒断症状评分较低 ,尤其是d4两组戒断症状评分有显著性差异(P<0.05),两组焦虑症状 ,脱毒率及美沙酮、丁丙诺啡平均用量无显著性差异。结论··:尼莫地平控释片对海洛因戒断症状有一定辅助治疗作用 ,尤其对忽冷忽热、腹痛、周身疼痛不适、心悸胸闷等戒断症状控制较好 。Objective: To observe the effect of calcium antagonists nimodipine controlled-release tablets(NCRT) as adjuvant therapy on heroin withdrawal syndrome. Methods: Thirty heroin addicts were treated with methadone and buprenorphine at tapered dose and administered orally NCRT 60 mg,bid meanwhile. The other 30 heroin addicts were treated with methadone and buprenorphine only as control. The duration of treatment was 10 days. Results: Patients with NCRT had their withdrawal syndromes better controlled, especially on the fourth day. However, there was no difference in the control of anxiety. The rate of abstinence and average dose of methadone and buprenorphine were the same. Conclusion: NCRT have some adjuvant therapeutic effects on heroin withdrawal syndrome, especially effective on the syndrome of fever alternates with chills, abdominal pain, body pain and malaise, palpitation and the feeling of tightly closed chest. It has no obvious adverse drug effect.

关 键 词：作用机理 尼莫地平控释片 辅助治疗 海洛因戒断综合征 

分 类 号：R595.5[医药卫生—内科学] R971[医药卫生—临床医学]