CIDE B/C基因多态性与高三酰甘油血症相关性研究  

The relation between gene polymorphisms of CIDE B/C and hypertriglyceridemia

作　　者：刘莉[1] 平智广[2] 詹芳芳[2] 戚敏杰[2] 黄忻[1] 

机构地区：[1]郑州大学基础医学院组织学与胚胎学教研室,郑州450001 [2]郑州大学公共卫生学院流行病与卫生统计学教研室,郑州450001

出　　处：《重庆医学》2016年第15期2061-2064,共4页Chongqing medicine

基　　金：国家自然科学基金资助项目(81001280;81202277);河南省科技攻关项目(112102310198)

摘　　要：目的通过分析CIDE B/C基因多态性的人群分布特征,探明CIDE B/C基因多态性与中国河南汉族人群血三酰甘油（TG）水平的关系。方法选取528例无亲缘关系研究对象,男198例,女330例,平均年龄（52.23±13.41）岁,以1.70mmol/L为TG界值,将研究对象分为高三酰甘油血症（HTG）组（181例）和正常三酰甘油组（NTG组,347例）。检测CIDE B/C基因的7个SNP,采用SHEsis进行基因单倍型研究,分析两种基因的单倍型与TG的关系。结果分析显示rs2144492、rs2281472、rs2144493位点与TG有关,其中rs2144492的A等位基因、rs2281472和rs2144493的C等位基因具有保护作用,携带上述等位基因的个体TG水平相对较低。CIDE B基因的ATCC单倍型在NTG组比例较高,具有保护作用,OR及其95%CI为0.698（0.490-0.992）。结论 CIDE B/C基因多态性及CIDE B基因的ATCC单倍型对HTG的发生风险存在一定作用。Objective To determine the possible effect of CIDEB/C gene polymorphism and haplotypes on hypertriglyceridemia（HTG）in Han group.Methods 528 unrelated subjects were selected（198 males,330females）with the mean age of52.23±13.41 years old.According to the criteria of triglyceride（TG）≥1.70mmol/L（150mg/dl）,181 persons were arranged into HTG（hypertriglyceridemia）group and 347 persons were in NTG（normal triglyceride）group.A total of 7SNPs in CIDEB and CIDEC genes were detected.The relationship between these ten SNPs and TG were analyzed under additive inheritance pattern by logistic regression.SHEsis online were used to get the haplotypes and their effects on TG.Results rs2144492,rs2281472 and rs2144493were associated with TG.The frequency of ATCC,haplotype of CIDEB,was higher in NTG group.OR and its 95%confidence interval was 0.698[0.490-0.992].Conclusion ATCC of CIDE B/C gene polymorphism may be related to the occurrence of HTG.

关 键 词：甘油三酯类 CIDE 基因多态性 单倍型 

分 类 号：R589.2[医药卫生—内分泌]