冠心病患者心外膜脂肪组织厚度与颈动脉弹性的相关性研究  

Study of correlation in epicardial adipose tissue thickness and carotid artery elasticity in patients with coronary heart disease

作　　者：李琛[1] 周文锐[1] 朱敏洁[2] 

机构地区：[1]同济大学附属杨浦医院老年二科,上海200092 [2]同济大学附属杨浦医院全科医学科/全科医学教研室,上海200092

出　　处：《临床和实验医学杂志》2016年第10期967-969,共3页Journal of Clinical and Experimental Medicine

摘　　要：目的分析冠心病患者心外膜脂肪层厚度与颈动脉弹性之间相关性。方法选取164例冠心病患者,分为对照组(单支病变狭窄率小于50%)(n=60)、单支病变组(n=44)、双支病变组(n=35)、三支病变组(n=25)。超声检测各组心外膜脂肪组织厚度(EAT),测量颈动脉内-中膜厚度(IMT),对血管的僵硬度(β)、弹性模量(Ep)、顺应性(AC)和膨大指数(AI)以及脉搏波传导速度(PWV-β)等重要指标进行计算,并比较分析。结果三支病变组的EAT显著大于双支病变组、单支病变组和对照组,双支病变组的EAT显著大于单支病变组和对照组(P均<0.05)。随着冠心病病变涉及区域持续扩展,颈动脉β、Ep、PWV-β皆显著增加,但是AC则骤减。EAT与颈动脉各项指标IMT、β、Ep、AC、PWV-β均具有较好相关性(r=0.623、0.564、0.495、-0.567、0.664,P均<0.05)。结论 EAT和颈动脉弹性指标均可以作为预测冠心病病变范围的重要方法,两者也具有较好的相关性,值得临床推广应用。Objective To investigate the correlation in epicardial adipose tissue thickness and carotid artery elasticity in patients with coronary heart disease. Methods 164 cases of coronary heart disease were collected and divided into four groups： control group（ single- vessel stenosis less than 50%）（ n = 60）,single- vessel disease group（ n = 44）,double- vessel disease group（ n = 35） and three- vessel disease group（ n = 25）. Ultrasonic testing was used in detecting epicardial adipose tissue thickness（ EAT） and carotid- thickness（ IMT）,and vascular stiffness（ β）. The elastic modulus（ Ep）,compliance（ AC）,swelling index（ AI）,pulse wave velocity（ PWV- β） and other indicators were measured and comparatively analyzed. Results EAT in the three- vessel disease was significantly greater than the two- vessel disease,single- vessel disease group and the control group. EAT in double- vessel disease group was significantly greater than the single- vessel disease group and the control group. As the lesions increased in coronary heart disease,carotid β,Ep,PWV- β were significantly increased,while the AC appears significantly reducing. EAT indicators had better correlation with carotid IMT,β,Ep,AC,PWV- β（ r = 0. 623,0. 564,0. 495,- 0. 567,0.664,P〈0. 05）. Conclusion EAT and carotid artery elasticity index can be used as an important method to predict range of coronary heart disease,also has a good correlation and worthy of clinical application.

关 键 词：冠心病 心外膜脂肪组织厚度 颈动脉弹性 

分 类 号：R541.4[医药卫生—心血管疾病]