成都地区城乡人群原发性骨质疏松调查  

The epidemiological investigation of primary osteoporosis patients in urban and rural area in Chengdu

作　　者：安珍[1] 王文志[1] 杨定焯[1] 马锦富[1] 赵元全[1] 赵立强[1] 唐婧[1] 

机构地区：[1]华西医科大学附四院骨质疏松诊疗中心,成都610041

出　　处：《中国骨质疏松杂志》2002年第3期233-236,共4页Chinese Journal of Osteoporosis

基　　金：国家"九五"科技攻关课题资助项目

摘　　要：目的　为了解成都地区城乡正常人群腰椎 ,髋部各部位骨密度 (BMD)随年龄变化的规律和原发性骨质疏松症 (OP)的患病情况及可能影响因素 ,为预防骨质疏松的发生提供科学依据。方法　用整群随机抽样方法 ,对成都地区≥ 2 0岁健康人群共抽取 14 6 0人 ,城市 6 6 2人 ,农村 798人 ,采用双能X线骨密度仪 (DEXA)测量腰椎 2～ 4正位 ,左股骨近段 (Neck ,Ward’s ,Troch)BMD值 ,按城乡、男女分别每 10岁一个年龄组进行统计分析。结果　男女骨量峰值 (PBM)均出现在 2 0～ 39岁 ,男性L2 - 4PBM为 (1 12 0± 0 114 )g cm2 ,女性为 (1 113± 0 113)g cm2 。 4 0岁以后随着年龄的增加城乡男女BMD逐渐下降 ,女性各部位BMD值下降明显高于男性 (P <0 0 1) ,其中女性 5 0岁和 6 0岁两年龄组骨量呈快速丢失阶段 ,骨量累积丢失率L2 - 4农村男性 17 9%、女性 35 3%均明显高于城市男性12 5 % ,女性 2 5 0 % ,而且股骨上端骨量累积丢失率明显高于腰椎。骨质疏松症患病率女性高于男性。结论　成都地区城乡男女骨峰值形成年龄段在 2 0～ 39岁 ,城市、农村不同性别年龄的BMD值4 0岁后随年龄增加而减少 ,女性BMD明显低于男性 ,骨量累积丢失率原发性骨质疏松症患病率女性高于男性 ,农村高于城市 ,各部位累积丢失率Ward’s>Objective\ To find out the changing pattern of bone mineral density(BMD)of lumbar spines and hip with aging in urban and rural area in Chengdu,and find out prevalence of primary osteoporosis and its possible influenced factros and provide scientific basis for osteoporosis prevention. Methods\ 1 460 healthy subjects in Chengdu aged 20 years and more than 20 years were randomly selected.Among them 662 subjects came from urban area and 798 subjects were from rural area.BMD of lumbar 2-4 and left proximal femur was measured by DEXA,then was analyzed by 10 years a group of male and female respectively. Results\ Peak bone mass (PBM) of both male and female were in age group of 20-30.PBM of lumbar 2-4 of male was (1 120±0 114)g/cm 2 and that of female was (1 113±0 113)g/cm 2.BMD was gradually declining with the increasing age after 40 years old.The magnitude of declining BMD of female was higher than that of male.The bone loss was faster in age groups of 50-59 and 60-69.The total loss rate of bone mass of lumbar 2-4 was 17 9% for male and 35 3% for female in rural area.The total loss rate of proximal femur was higher than that of lumber vertebra.The prevalence of osteoporosis of female was higher than that of male. Conclusions\ In order to elevate PBM,it is important to take food rationally and strengthen physical activities during puberty.After 50 years old,the aged shuld be complemented with adequate calcium and nutrients,the postmenopausal women should be treated with estrogen replacement therapy.So it can reduce bone loss and slow down the progress of primary osteoporosis.\;

关 键 词：成都市 原发性骨质疏松 流行病学 影响因素 骨密度 患病率 

分 类 号：R681[医药卫生—骨科学]