抗核抗体和抗心磷脂抗体对宫颈机能不全孕妇的临床意义  

Clinical significance of antinuclear antibody and anticardiolipin antibody to pregnant women diagnosed with cervical incompetence

作　　者：高琳[1] 徐友文[1] 王佐君[1] 

机构地区：[1]台州市中心医院检验中心,浙江台州318000

出　　处：《中国卫生检验杂志》2016年第9期1285-1287,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的探讨抗核抗体和抗心磷脂抗体对宫颈机能不全孕妇的临床意义。方法选择本院就诊并诊断为宫颈机能不全的患者147例作为观察组,健康孕产妇150例为对照组。比较2组孕妇ACA和ANA阳性率,宫颈机能不全患者中,将晚期流产史1次、2次～3次、〉3次分别划分为A组、B组、C组,比较各组的ACA和ANA抗体阳性率。结果观察组ACA阳性率（34.69%）与对照组（8.67%）相比,差异有统计学意义;观察组ANA阳性率（31.29%）与对照组（7.33%）相比,差异有统计学意义;观察组ACA与ANA均阳性的比率（23.13%）与对照组（2.67%）相比,差异有统计学意义。观察组中A组、B组、C组的ACA阳性率分别为22.78%、35.00%、67.86%,两两差异比较均有统计学意义（P〈0.05）;A组、B组、C组的ANA阳性率分别为25.32%、32.50%、46.43%,两两比较差异均有统计学意义（P〈0.05）。结论抗心磷脂抗体与抗核抗体水平检测对宫颈机能不全孕妇有重要辅助诊断、指导治疗的意义。Objective To explore the clinical significance of antinuclear antibody and anticardiolipin antibody to pregnant women with cervical incompetence. Methods 147 pregnant women diagnosed with cervical incompetence in our hospital were selected as observation group,while 150 cases of healthy pregnant women at the same period were selected as control group.Compared the positive rates of ACA and ANA between two groups. To divide the observation group into A,B,C groups according to the times of late abortion（ 1,2- 3,≥ 3）,and compare the positive rates of ACA and ANA among the groups.Results The positive rate of ACA of observation group（ 34. 69%） was significantly higher than that of control group（ 8. 67%）,with the difference statistically significant. The positive rates of ANA of observation group（ 31. 29%） was significantly higher than that of control group（ 7. 33%）,with the difference statistically significant. The difference on average positive rates of ACA and ANA between the observation group（ 23. 13%） and the control group（ 2. 67%） was statistically significant. The positive rates of ACA were respectively 22. 78% in group A,35. 00% in group B,67. 86% in group C,and statistical significance was found on the differences between each two groups（ P 〈0. 05）; the positive rates of ANA were respectively 25. 32% in group A,32. 50% in group B,and 46. 43% in groups C,and statistical significance was found on the differences between each two groups（ P 〈0. 05）. Conclusion Antinuclear antibody and anticardiolipin antibody detection has important clinical significance to pregnant women diagnosed with cervical incompetence,including accessory diagnostic value and helping guide treatment.

关 键 词：宫颈机能不全 抗心磷脂抗体 抗核抗体 孕妇 

分 类 号：R446.6[医药卫生—诊断学]