胸痛患者血浆GDF15水平与冠状动脉病变的相关性  

Correlation between plasma GDF15 and coronary artery stenosis in patients with chest pain

作　　者：朱园园[1] 叶益聪[2] 张抒扬[2] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院内科,北京100730 [2]中国医学科学院北京协和医学院北京协和医院心内科,北京100730

出　　处：《基础医学与临床》2016年第6期830-834,共5页Basic and Clinical Medicine

摘　　要：目的评价胸痛患者血浆生长分化因子15(GDF15)水平与冠状动脉病变的相关性。方法记录158例住院行常规冠状动脉造影(CAG)患者的临床资料,按照CAG结果将患者分为冠状动脉粥样硬化性心脏病(CAD)组(n=108)和非CAD组(n=50),在CAG前采集所有患者动脉血样,用酶联免疫吸附法测定患者血浆GDF15浓度,按照CAG结果以Gensini评分评价所有患者冠状动脉病变程度。结果 CAD组的血浆GDF15浓度为(605±205)ng/L,显著高于非CAD组的(359±155)ng/L(P<0.001)。胸痛患者血浆GDF15水平与Gensini评分呈显著正相关(r=0.555,P<0.001)。多重线性回归分析显示GDF15水平与Gensini评分的相关性独立于其他CAD危险因素(P<0.001)。结论血浆GDF15水平可以作为胸痛患者冠状动脉病变程度的预测指标。Objective To find the correlation between growth differentiation factor 15（ GDF15） plasma level and coronary artery stenosis in patients with chest pain. Methods 158 patients with chest pain were divided into coronary atherosclerotic heart disease（ CAD） group（ n = 108） and non-CAD group（ n = 50） according to the results of coronary artery angiography（ CAG）. Blood samples were obtained before CAG from all patients. GDF15 level was determined by enzyme linked immuno-sorbent assay. Gensini score was used to evaluate the severity of coronary artery stenosis. Results GDF15 level of the CAD group and non-CAD group were（ 605 ± 205） ng / L and（ 359 ±155） ng / L respectively（ P〈0. 001）. GDF15 level was positively related to Gensini score in patients with chest pain（ r = 0. 555,P〈0. 001）,and multiple linear regression analysis showed that circulating level of GDF15 was independently related to Gensini score of the coronary artery（ P〈0. 001）. Conclusions GDF15 is a potential biochemical marker for the prognosis of coronary artery stenosis in patients with chest pain.

关 键 词：生长分化因子15 冠状动脉粥样硬化性心脏病 生化标记物 

分 类 号：R54[医药卫生—心血管疾病]