氨基葡萄糖联合臭氧治疗膝骨关节炎的临床研究  

The Clinical Research on Combined Glucosamine and Ozone in the Treatment of Knee Osteoarthritis

作　　者：范文江[1] 刘庆 

机构地区：[1]内江市第一人民医院疼痛科,四川内江641000 [2]西南医科大学附属中医医院疼痛科

出　　处：《华西医学》2016年第5期823-826,共4页West China Medical Journal

摘　　要：目的探讨口服盐酸氨基葡萄糖片联合臭氧膝关节腔注射治疗膝骨关节炎的疗效和安全性。方法选择2014年1月-2015年1月符合要求的72例中度膝骨关节炎患者,通过随机数字表法分为联合组和臭氧组。联合组患者连续口服盐酸氨基葡萄糖片(0.48 g/次,3次/d,口服)12周,治疗最初4周,每周为患者膝关节腔注射臭氧1次;臭氧组是将联合组治疗中的盐酸氨基葡萄糖片换成盐酸氨基葡萄糖模拟片(2片/次,3次/d,口服),其余治疗相同。记录治疗前和治疗后第1、3、6个月视觉模拟评分(VAS)、西安大略和麦克马斯特大学骨关节炎指数(WOMAC评分)及不良反应。结果治疗后第1、3、6个月,两组患者VAS、WOMAC评分与治疗前差异均有统计学意义(P<0.05);治疗后第1个月,两组间VAS、WOMAC评分差异无统计学意义(P>0.05);治疗后第3、6个月,两组患者VAS、WOMAC评分差异有统计学意义(P<0.05)。治疗过程两组患者均未见明显不良反应。结论氨基葡萄糖联合臭氧或单纯臭氧治疗中度膝骨关节炎疗效确切且无不良反应;氨基葡萄糖联合臭氧治疗中度膝骨关节炎,远期效果更佳,值得临床推广。Objective To discuss the efficacy and safety of the joint application of oral glucosamine hydrochloride tablets and knee joint cavity ozone injection in the treatment of knee osteoarthritis. Methods From January 2014 to January 2015, 72 patients who matched the criteria of moderate knee osteoarthritis were randomly divided into two groups according to the table of random number： oral glucosamine hydrochloride tablet and knee joint cavity ozone injection group （group G＋O） and ozone group （group O）. Patients of group G＋O orally took glucosamine hydrochloride tablets （0.48 g, 3 times/day） for twelve weeks, and ozone was injected into the patients＇ knee joint once a week for the first four weeks. The treatment for group O patients was the same with Group G＋O, except that the glucosamine hydrochloride tablets were replaced by glucosamine hydrochloride placebo （2 tablets, 3 times/day, taking orally）. We recorded the Visual Analogue Scale （VAS） score, Western Ontario ＆ McMaster University （WOMAC） osteoarthritis index score and the adverse reactions before treatment and in the first, third and sixth month after treatment. Results Patients＇ VAS scores and WOMAC scores of both the two groups in the first, third and sixth month after treatment were significantly different from those before the treatment （P 〈 0.05）. In the first month after treatment, there were no significant difference in patients＇ VAS scores and WOMAC scores between the two groups （P ~ 0.05）. In the third and sixth month after treatment, there were significant differences in patients＇ VAS scores and WOMAC scores between the two groups （P 〈： 0.05）. There was no obvious adverse reactions during the treatment. Conclusions The combined application of oral glucosamine hydrochloride tablets and knee joint cavity ozone injection and the ozone treatment for moderate knee osteoarthritis are both effective, without any adverse reaction. The combined treatment of oral glucosamine hydrochloridetablets and kn

关 键 词：臭氧 氨基葡萄糖 骨关节炎 膝 

分 类 号：R684.3[医药卫生—骨科学]