更昔洛韦联合强的松和人免疫球蛋白治疗中老年重症带状疱疹42例  

Ganciclovir Combined with Prednisone and Human Immunoglobulin in the Treatment of Serious Herpes Zoster in Middle- Aged and Elderly Patients

作　　者：雷田兵[1] 罗模桂[1] 刘官智[1] 

机构地区：[1]四川省自贡市第四人民医院,四川自贡643000

出　　处：《中国药业》2016年第9期84-87,共4页China Pharmaceuticals

摘　　要：目的探讨更昔洛韦联合强的松和人免疫球蛋白治疗中老年重症带状疱疹的疗效。方法将带状疱疹患者按就诊顺序随机分为两组,观察组42例,予以更昔洛韦和强的松（0.5 mg/kg·d）联合小剂量丙种球蛋白（2.5-5 g）治疗;对照组38例,仅予更昔洛韦和强的松治疗。观察两组患者的止疱时间、开始结痂时间、完全脱痂时间、住院时间,治疗第4天、第8天及1个月、2个月时的疼痛情况[疼痛视觉模拟（VAS）评分]及疗效。结果观察组较对照组在皮损止疱时间、开始结痂时间、完全脱痂时间、住院时间均明显减少（t=4.93,6.12,2.82,3.20,P〈0.05）;观察组较对照组在治疗第4天、第8天、1个月、2个月时的VAS评分明显减少（t=2.40,3.34,3.12,3.31,P〈0.05）,后遗神经痛减少;观察组有效率明显高于对照组（χ2=3.90,P〈0.05）。结论更昔洛韦联合强的松和小剂量人免疫球蛋白可明显提高中老年重症带状疱疹患者的疗效,促进皮损的恢复,减少后遗神经痛发生。Objective To evaluate the efficacy of ganciclovir combined with prednisone and human immunoglobulin for treating serious herpes zoster in middle- aged and elderly patients. Methods Patients with herpes zoster were randomly divided into two groups in ac-cordance with the order of treatment patients, the observation group with 42 patients was treated with ganciclovir plus prednisone（ 0. 5 mg / kg·d） combined with low dose of human immunoglobulin（ 2. 5- 5 g）, and the control group with 38 patients was treated without using human immunoglobulin. The blister stop time, scab beginning time, complete decrustation time and hospitalization time, as well as the visual analogue scale（ VAS） 4, 8 d, 1, 2 month after treatment were observed in the two groups. Results The blister stop time,scab beginning time, complete decrustation time and hospitalization time of the observation group were obviously lower than those of the control group（ t = 4. 93, 6. 12, 2. 82, 3. 20, P〈 0. 05）. The VAS scores 4, 8 d, 1, 2 month after treatment of the observation group were obviously lower than the control group（ t = 2. 40, 3. 34, 3. 12, 3. 31, P〈 0. 05）, the neuralgia incidence was also obviously reduced, and the effective rate in the observation group was obviously higher than that of the control group（ χ2= 3. 90, P〈 0. 05）. Conclusion Ganciclovir plus prednisone combined with low dose human immunoglobulin can significantly improve the treatment of elderly patients with severe herpes zoster, and promote the recovery of skin lesions, reducing the incidence of postherpetic neuralgia.

关 键 词：更昔洛韦 强的松 人免疫球蛋白 带状疱疹 

分 类 号：R969.4[医药卫生—药理学] R978.7[医药卫生—药学]