饮酒与女性乳腺癌发病关系的病例对照研究  

Association between Alcohol Drinking and Breast Cancer Risk: A Case-control Study

作　　者：罗伟平[1] 严波[1] 杜雨峰[1] 徐铭[1] 莫雄飞[2] 张彩霞[1] 

机构地区：[1]中山大学公共卫生学院医学统计与流行病学系,广东广州510080 [2]中山大学附属第一医院甲状腺乳腺外科,广东广州510080

出　　处：《中山大学学报（医学科学版）》2016年第3期475-480,F0003,共7页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：国家自然科学基金(81102188);广州市科技计划项目科学研究专项(201510010151)

摘　　要：[目的]探讨饮酒与女性乳腺癌发病的关系.[方法]采用以医院为基础的病例对照研究设计,在中山大学两家附属医院于2007年6月到2015年10月间收集确诊的女性乳腺癌患者（1 268例）和同时期同医院就诊的非肿瘤患者（1268例）,调查其社会人口学特征、膳食习惯、月经生育史、疾病及家族史、生活方式和体力活动情况.采用多因素非条件logistic回归模型分析饮酒与乳腺癌发病的关系.[结果]1268例病例和1268例对照的平均年龄分别为（47.35±9.69）和（47.18±9.97）岁,其中172例（13.6％）病例和104例（8.2％）对照有饮酒习惯.Logistic回归模型中调整了体质指数、教育程度、家庭收入、体力活动、被动吸烟、一级亲属乳腺癌史、良性乳腺病史和口服避孕药,结果显示饮酒与乳腺癌存在正相关[odds ratio（OR）=1.76,95％ confidence interval（CI）=1.35～2.30],且随着饮酒频率、饮酒时长和饮酒量的增加,女性患乳腺癌的危险性逐渐增高（P趋势均小于0.01）.不同饮酒类型与乳腺癌关系的结果显示,饮用白酒、葡萄酒、啤酒均与乳腺癌发病存在正相关.[结论]本研究提示饮酒可能会增加女性罹患乳腺癌的风险,此作用仅限于白酒、葡萄酒和啤酒.[ Objective ] To examine the association between alcohol drinking and breast cancer risk. [ Methods ] A hospital-based case-control study was conducted and we recruited a total of 1 268 breast cancer cases and 1 268 controls hospitalized in two affiliated hospitals of Sun Yat-sen University between June 2007 and October 2015. The information on socio-demographic factors, dietary habits, menstrual and reproductive histories, disease and family histories, living habits and physical activity was collected. Multivariate unconditional logistic regression models were used to estimate the association between alcohol drinking and breast cancer risk. [Results] The mean （standard deviation） age of cases and controls were 47.35 （9.69） and 47.18 years （9.97）, respectively. And 172 cases （ 13.6 %） and 104 （8.2 %） controls drank alcohol. We controlled for the factors in the logistic regression models, such as body mass index, education, family income, physical activity, passive smoking, family history of breast cancer, history of benign breast disease and ever used an oral contraceptive use. A positive correlation was found between alcohol drinking and breast cancer risk [ odds ratio （OR） = 1.76, 95% confidence interval （CI） = 1.35 - 2.30）], with significant dose-response relationships in terms of frequency, duration and amount of alcohol drinking （Ptrend 〈 0.01）. Consumptions of white spirit, grape wine and beer were found to increase the risk of breast cancer. [ Conclusion ] This study suggests that alcohol drinking might increase the risk of breast cancer. The effect might only appear in women consumers of white spirit, grape wine and beer.

关 键 词：饮酒 乳腺癌 病例对照研究 

分 类 号：R1[医药卫生—公共卫生与预防医学]