噁二唑-2-氧化物合成及抗日本血吸虫尾蚴活性  

Synthesis of Oxadiazole-2-Dxide Analogues as Anti-Schistosoma Japonicum Cercaria Agents

作　　者：钱益平 郭同 陈祥钊 唐勇 申昌德 许祖波 李勋[1] 范小林 

机构地区：[1]赣南师范学院化学化工学院,江西赣州341000

出　　处：《赣南师范学院学报》2016年第3期33-36,共4页Journal of Gannan Teachers' College(Social Science(2))

基　　金：国家自然科学基金项目(21302022)

摘　　要：以苯丙烯醇为原料合成噁二唑-2-氧化物,并对其进行结构表征确认,评价其抗日本血吸虫尾蚴活性.结果表明,噁二唑-2-氧化物具有不同程度的杀灭尾蚴活性,其中4-苯基-1,2,5-噁二唑-3-醛基-2-氧化物杀灭尾蚴活性最好.A series of oxadiazoles-2-oxide analogues were synthesized by benzene propylene glycol as raw material,and their structures were confirmed by ^1 H NMR and EI-MS,and their anti-schistosoma japonicum cercaria activities were evaluated. The results showed that the drugs had obvious the activity against schistosoma japonicum cercaria. Among them,the compound 4-phenyl-1,2,5-oxadiazoles-3-aldehyde-2-oxide had a best effect on anti-schistosoma japonicum cercaria.

关 键 词：噁二唑-2-氧化物 日本血吸虫 尾蚴 活性 

分 类 号：O626.27[理学—有机化学]