帕瑞昔布钠对甲状腺次全切除术患者术后镇痛的效果观察  

Observation on the analgesic effect of parecoxib sodium on patients undergoing subtotal thyroidectomy

作　　者：孙秀荣[1] 姜妍[1] 马晓霞[1] 

机构地区：[1]中国医科大学附属盛京医院外科,沈阳110004

出　　处：《实用药物与临床》2016年第5期599-601,共3页Practical Pharmacy and Clinical Remedies

摘　　要：目的观察用帕瑞昔布钠对甲状腺次全切除术患者进行术后镇痛的临床效果。方法将2014年11月至2015年11月期间在我院进行甲状腺次全切除术的105例患者随机分为3组。手术结束前15 min,给予静脉注射帕瑞昔布钠40 mg(A组)。患者术后返回病房后即刻静脉注射帕瑞昔布钠40 mg(B组)。手术结束前15 min给予静脉注射生理盐水2 m L溶药(C组)。每组35例。对三组患者术后返回病房即刻及2、4、6、12、24 h疼痛视觉模拟评分(VAS评分),术后1 d镇痛满意率和不良反应的发生率进行比较。结果 A组和B组患者在各时间点的VAS评分均显著低于C组,差异有统计学意义(P<0.05),A组术后0、2 h上述指标低于B组,差异有统计学意义(P<0.05)。三者患者术后不良反应发生率比较差异无统计学意义(P>0.05)。结论甲状腺次全切除术应用帕瑞昔布镇痛,能够降低术后疼痛,镇痛效果满意、安全可靠,手术结束前15 min给予静脉注射帕瑞昔布效果更好。Objective To discuss the analgestic effect of parecoxib sodium on patients who have undergone subtotal thyroidectomy. Methods We collected the clinical data of 105 cases who had undergone subtotal thyroidectomy in our hospital from November 2014 to November 2015. The patients were given intravenous injection of parecoxib sodium（ 40 mg） 15 minutes before the end of operation（ group A）. The patients were given intravenous injection of parecoxib sodium（ 40 mg） immediately after patients returned to the wards（ B group）. The patients were given intravenous injection of NS（ 2 mL） solution 15 minutes before the end of operation（ group C）. Each group included 35 cases.After returning to the ward,visual simulation pain score（ VAS score） was made 0,2,4,6, 12, 24 h later,postoperative analgesia satisfaction rate 1 d after operation and the incidence of side effects of the three groups were observed and compared. Results The VAS scores of A and B groups at each time point were significantly lower than that of C group, the difference was statistically significant（ P〈0. 05）; the VAS scores of A group（ 0,2hour） were lower than those of B group, the difference was statistically significant（ P〈0. 05）. The postoperative occurrence rate of side reactions of the three groups had no statistical significance（ P〉0. 05）. Conclusion Application of parecoxib during or after thyroid subtotal surgery can reduce postoperative pain and increase satisfaction of analgesic effect. Moreover, application of parecoxib is safe and reliable. Giving intravenous injection of parecoxib sodium 15 minutes before the end of surgery is a better choice.

关 键 词：帕瑞昔布 甲状腺次全切除术 术后镇痛 

分 类 号：R614[医药卫生—麻醉学]