Long Non-coding RNAs in the Cytoplasm  

作　　者：Farooq Rashid Abdullah Shah Ge Shan 

机构地区：[1]CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science,School of Life Sciences, University of Science and Technology of China

出　　处：《Genomics, Proteomics & Bioinformatics》2016年第2期73-80,共8页基因组蛋白质组与生物信息学报（英文版）

基　　金：supported by the National Basic Research Program of China (973 Program; Grant No. 2015CB943000);the National Natural Science Foundation of China (Grant Nos. 91519333 and 31471225);the Fundamental Research Funds for the Central Universities (Grant No. WK2070000034)

摘　　要：An enormous amount of long non-coding RNAs（lnc RNAs） transcribed from eukaryotic genome are important regulators in different aspects of cellular events. Cytoplasm is the residence and the site of action for many lncRNAs. The cytoplasmic lncRNAs play indispensable roles with multiple molecular mechanisms in animal and human cells. In this review, we mainly talk about functions and the underlying mechanisms of lncRNAs in the cytoplasm. We highlight relatively well-studied examples of cytoplasmic lncRNAs for their roles in modulating mRNA stability,regulating m RNA translation, serving as competing endogenous RNAs, functioning as precursors of microRNAs, and mediating protein modifications. We also elaborate the perspectives of cytoplasmic lncRNA studies.An enormous amount of long non-coding RNAs（lnc RNAs） transcribed from eukaryotic genome are important regulators in different aspects of cellular events. Cytoplasm is the residence and the site of action for many lncRNAs. The cytoplasmic lncRNAs play indispensable roles with multiple molecular mechanisms in animal and human cells. In this review, we mainly talk about functions and the underlying mechanisms of lncRNAs in the cytoplasm. We highlight relatively well-studied examples of cytoplasmic lncRNAs for their roles in modulating mRNA stability,regulating m RNA translation, serving as competing endogenous RNAs, functioning as precursors of microRNAs, and mediating protein modifications. We also elaborate the perspectives of cytoplasmic lncRNA studies.

关 键 词：IncRNA mRNA stability mRNA translation ceRNA MICRORNA 

分 类 号：Q343[生物学—遗传学]