凋亡抑制基因Bcl-2与支气管哮喘的关系  

Exploration of the relationship between B-cell lymphoma gene 2 and bronchial asthma

作　　者：伏杭江[1] 丁忠海[1] 马元 杜方翀 

机构地区：[1]南京军区南京总医院干部保健科,南京210002 [2]南京医科大第一附属医院呼吸科,南京210029 [3]解放军第三一六医院医务处,北京100093

出　　处：《中国医师杂志》2016年第5期797-800,共4页Journal of Chinese Physician

摘　　要：Bcl-2被认为是抑制细胞凋亡最重要的调控基因,支气管哮喘（哮喘）时Bcl-2表达增加.通过药物干预影响信号传导途径,下调Bcl-2表达水平,诱导程序化细胞死亡反应,可能成为哮喘治疗的靶点.笔者就Bcl-2的结构特点、调控凋亡的机制、对哮喘相关细胞的作用以及与哮喘的关系综述如下.The B-cell lymphoma gene 2 （Bcl-2） is considered as the most important inhibiting cell apoptosis control gene,and its expression is up-regulated in asthma.Drug intervention against Bcl-2 affects signal pathways,down-regulates the Bcl-2 expression,and induces programmed cell death.It may become the target of asthma treatment.This article reviews the structure characteristics of the Bcl-2,the mechanism of regulating apoptosis,and its role in asthma.

关 键 词：基因 BCL-2 哮喘 综述 

分 类 号：R562.25[医药卫生—呼吸系统]