Ⅴ型狼疮性肾炎合并抗中性粒细胞胞质抗体相关性血管炎  

Type Ⅴ lupus nephritis with anti-neutrophil cytoplasmic antibody associated vasculitis

作　　者：杨茜[1] 葛永纯[1] 程震[1] 刘志红[1] 

机构地区：[1]南京军区南京总医院肾脏科国家肾脏疾病临床医学研究中心全军肾脏病研究所,南京210016

出　　处：《肾脏病与透析肾移植杂志》2015年第6期582-586,共5页Chinese Journal of Nephrology,Dialysis & Transplantation

摘　　要：40岁女性,病程1月,持续肉眼血尿伴纳差、消瘦起病,肾损害表现为急进性肾炎综合征,MPO-ANCA高滴度阳性伴多种自身抗体阳性(ANA、Sm、A-β2-GP1)、补体C3下降及Coomb'试验阳性,肾活检示新月体肾炎伴肾小球膜性病变,诊断为Ⅴ型狼疮性肾炎合并ANCA相关性血管炎,经甲泼尼龙冲击治疗及行血浆置换后血清肌酐降至正常,MPO-ANCA及ANA滴度下降。A 40-years-old woman was characterized by gross hematuria, emaciation and rapidly progressive glomerulonephritis. Her serum MPO-ANCA was positive and a variety of autoantibodies （ ANA, SM, A-beta 2-GP1） were also positive, complement C3 decreased and Coombs- test was positive. Renal biopsy showed crescentic glomerulonephritis with membranous nephropathy. The diagnosis was type V lupus with ANCA associated vasculitis. After treatment of methylprednisolone pulse therapy and plasma exchange, the serum creatinine returned to normal and MPO-ANCA and ANA titer decreased.

关 键 词：狼疮性肾炎 抗中性粒细胞胞质抗体 血浆置换 

分 类 号：R593.242[医药卫生—内科学]