多指标联合检测评价维生素C治疗糖尿病合并胃溃疡的效果  

The evaluation of vitamin C for the treatment in diabetic gastric ulcers by multi-parameters detection

作　　者：李文媛[1] 宋丽华[1] 

机构地区：[1]长治医学院药学系,山西长治046000

出　　处：《中国医学装备》2016年第5期116-119,共4页China Medical Equipment

摘　　要：目的:探讨维生素C对糖尿病合并胃溃疡患者的治疗效果。方法:选取53例糖尿病合并胃溃疡患者,根据患者就诊ID号顺序将其分为对照组(23例)和干预组(30例)。两组患者均给予降血糖和抗幽门螺杆菌(HP)三联治疗,干预组同时给予维生素C口服。使用卡式幽门螺杆菌检测仪检测幽门螺杆菌,6个月后复查两组病例的血糖、血脂、胃溃疡及炎症指标,并进行统计分析。结果:治疗后两组患者的空腹血糖(FPG)、餐后2 h血糖(2h PG)、糖化血红蛋白(HbA1c)、胆固醇(TC)和甘油三酯(TG)均显著改善,两组相比干预组改善情况明显优于对照组,其差异显著(t=1.23,t=1.35,t=2.63,t=1.07,t=0.77;P<0.05);两组的胃液 H值、血清胃蛋白酶(PGⅠ)、胃蛋白酶(PGⅡ)和PGⅠ/PGⅡ均明显改善,两组相比干预组改善程度显著优于对照组,其差异显著(t=1.45,t=1.67,t=2.33,t=1.55;P<0.05)。结论:维生素C对糖尿病合并胃溃疡患者的血糖、血脂、胃功能及炎症反应均有很好的治疗及预防作用,同时,卡式幽门螺杆菌检测仪能简化对幽门螺杆菌的检测。Objective：To investigate the intervention effect of vitamin C for the treatment to diabetes patients with diabetes and gastric ulcer.Methods： 53 cases of patients with diabetes combined with gastric ulcer were selected as the research subjects, and were divided into a control group（23） and a intervention group（30）. The patients in two groups were given the treatment of reducing blood sugar and anti-HP triple therapy. The intervention group was given additionally diet intervention via eating vitamin C. The blood sugar, blood lipid levels, gastric ulcer index and inflammatory markers of the two groups were reviewed six months later by helicobacter pylori type detector. And the statistical analysis was performed.Results： After treatment, the blood sugar, blood lipid levels, gastric ulcer index and inflammatory markers of the two groups were significantly improved （t=1.23,t=1.35,t=2.63,t=1.07,t=0.77,P〈0.05）, except for the HP cure rate （P〉0.05）. Other indexes of the intervention group are significantly better than the control group （t=1.45,t=1.67,t=2.33, t=1.55,P〈0.05）.Conclusion：Vitamin C play a very good role in the treatment and prevention for the blood sugar, the blood lipids, gastric function and inflammation of patients with diabetes and gastric ulcer, and helicobacter pylori type detector can simplify the detection of helicobacter pylori.

关 键 词：卡式幽门螺杆菌检测 维生素C 糖尿病 胃溃疡 

分 类 号：R587.1[医药卫生—内分泌]