子痫前期患者血清与胎盘组织中一氧化氮的表达及其意义  

Expressions and significance of nitric oxide in serum and placenta of patients with preeclampsia

作　　者：卢敏[1] 黄珊萍[1] 郑林媚[1] 许艳[1] 

机构地区：[1]海南省人民医院产科,海南海口570311

出　　处：《中国妇幼保健》2016年第11期2253-2256,共4页Maternal and Child Health Care of China

基　　金：海南省自然科学基金(琼科814320);海南省卫生厅普通科研项目(琼卫13A210303)资助

摘　　要：目的探讨子痫前期(PE)患者血清与胎盘组织中一氧化氮(NO)的表达及其意义。方法选取轻度、重度PE患者各20例,分别作为B组和A组,另选同期行剖宫产的单胎初产健康妊娠妇女20例作为对照组(N组)。比较3组患者的平均动脉压(MAP)、24h尿蛋白量,在入院时(T0)、产前(T1)及产后6h(T2)的血清NO水平,以及胎盘组织的NO和环磷酸鸟苷(cGMP)水平。结果 A组、B组患者MAP在T0、T1、T2时点均明显高于N组,差异有统计学意义(A组MAP在T0、T1、T2时点与N组比较t=4.126、3.659、2.922;B组MAP在各时点与N组比较t=3.326、2.685、2.227,均P<0.05),A组和B组T2时点MAP均较T0有明显降低,差异有统计学意义(t=3.243、2.826,均P<0.05)。A组、B组24h尿蛋白定量值显著高于N组,差异有统计学意义(t=13.462、9.698,均P<0.05)。A组、B组血清NO水平在T0、T1、T2时点均显著低于N组,差异有统计学意义(A组血清NO水平在T0、T1、T2时点与N组比较t=5.686、3.452、2.706;B组血清NO水平在T0、T1、T2时点与N组比较t=3.012、2.842、2.361,均P<0.05),且A组比B组降低更明显,差异有统计学意义(A组血清NO水平在各时点与B组比较,t=2.546、2.318、2.109,均P<0.05)。A组、B组血清NO水平在T0、T1、T2时点逐渐增加,差异有统计学意义(A组血清NO水平在T2时点与T1比较,T1时点与T0比较,t=3.090、2.142;B组血清NO水平在T2时点与T1比较,T1时点与T0比较,t=3.106、2.329,均P<0.05)。3组患者血清NO水平与MAP(r=-0.681,P<0.05)和24h尿蛋白定量(r=-0.358,P<0.05)均呈负相关关系。A组、B组胎盘组织NO水平和cGMP浓度均显著低于N组,差异有统计学意义(B组、A组NO水平与N组比较,t=2.633、3.857,B组、A组cGMP浓度与N组比较t=2.846、3.824,均P<0.05)。3组患者胎盘组织中cGMP浓度与NO水平呈正相关关系(r=0.572,P<0.05)。结论孕妇血清与胎盘组织中NO水平与PE发病及病情轻重密切相关。Objective To explore the expressions and significance of nitric oxide （NO） in serum and placenta of patients with preeclampsia. Methods Twenty mild preeclampsia patients and twenty severe preeclampsia patients were selected as B group and A group, respectively; twenty healthy pregnant women of single pregnancy undergoing cesarean section during the same period were selected as N group （control group） . Mean arterial pressure （MAP）, 24-hour urine protein, serum NO levels at admission （T0）, before delivery （T1）, and at six hours after delivery （ T2 ）, placental NO and cyclic guanosine monophosphate （cGMP） levels in the three groups were compared. Results MAP levels at T0, T1 , and T2 time points in A group and B group were statistically significantly higher than those in N group （comparison between A group and N group： t=4. 126, 3. 659, 2. 922, P〈0. 05; comparison between B group and N group： t = 3. 326, 2. 685, 2. 227, P〈0. 05） . In A group and B group, MAP levels at T2 time point were statistically significantly lower than those at TO time point （t = 3. 243, 2. 826, P〈0.05） . In A group and B group, 24-hour urine protein contents were statistically significantly higher than those in N group （ t = 13.462, 9. 698, P〈0.05） . Serum levels of NO at T0, T1, and T2 time points in A group and B group were statistically significantly lower than those in N group （ comparison between A group and N group ： t = 5. 686, 3.452, 2. 706, P〈0. 05 ; comparison between B group and N group： t=3. 012, 2. 842, 2. 361, P〈0. 05）, especially in A group （comparison between A group and B group： t=2. 546, 2. 318, 2. 109, P〈0. 05） . Serum levels of NO at T0 , T1 , and T2 time points in A group and B group increased gradually, there were statistically significant differences （comparison between T2 time point and T1 time point in A group： t = 3. 090, P〈0.05; comparison between T1 time point and TO time point in A group： t = 2. 142, P〈0. 05; comparison between T2 t

关 键 词：一氧化氮 子痫前期 环磷酸鸟苷 血压 

分 类 号：R714.245[医药卫生—妇产科学]