Chemerin在妊娠期糖尿病孕妇不同孕周中的表达及意义  

Expression and significance of Chemerin in pregnant women with gestational diabetes mellitus during different gestational weeks

作　　者：杜习羽[1] 俞泓[1] 董玉楠[1] 

机构地区：[1]南方医科大学附属深圳妇幼保健院,广东深圳518028

出　　处：《中国妇幼保健》2016年第11期2256-2259,共4页Maternal and Child Health Care of China

基　　金：深圳市科技创新委员会知识创新计划基础研究项目(20130328230547)

摘　　要：目的了解妊娠期糖尿病(gestational diabetes mellitus,GDM)孕妇在不同孕周血清Chemerin水平的变化及其临床意义。方法采用酶联免疫吸附法测定171例GDM患者(GDM组)及42例糖耐量正常孕妇(对照组)孕中期及孕晚期的血清Chemerin水平,同时测定受试者空腹血糖(FPG)、空腹胰岛素(FINS)、不同孕期的BMI数值等,计算胰岛素抵抗指数(HOMA-IR)。结果 GDM组在孕中期及孕晚期时的空腹胰岛素、HOMA-IR及Chemerin均明显高于对照组(P<0.05)。两组孕妇血清Chemerin在孕中期及孕晚期时与空腹胰岛素及HOMA-IR均呈正相关(P<0.05),其中GDM组呈高度正相关,对照组呈中度正相关。而两组孕妇血清Chemerin在孕中晚期时与空腹血糖、服糖后1h血糖、服糖后2h血糖、BMI值均低度相关(|r|<0.05)、不相关(|r|<0.3)或无统计学意义(P>0.05)。GDM组孕妇空腹胰岛素在孕中期和孕晚期对比,检验结果无统计学意义(P>0.05),而Chemerin在孕晚期时较孕中期数值升高(P<0.01),空腹血糖和HOMA-IR在孕晚期时较孕中期数值降低(P<0.01)。正常组孕妇四项数值在孕中期和孕晚期对比检验结果均无统计学意义(P>0.05)。结论Chemerin与胰岛素抵抗及GDM发病密切相关,且Chemerin数值不受即时血糖高低的干扰,能反映出GDM孕妇的胰岛素敏感状态,可能对GDM孕妇是否将来易患2型糖尿病起预测指标的作用。Objective To understand the change of serum Chemerin levels in pregnant women with gestational diabetes mellitus （GDM） during different gestational weeks. Methods The levels of serum Chemerin in 171 GDM patients （ GDM group） and 42 pregnant women with normal glucose tolerance （control group） during the second and the third trimesters of pregnancy were detected by ELISA; fasting plasma glucose （FPG） and fasting insulin levels （FINS）, body mass index （BMI） during different stages of pregnancy were detected, insulin resistance index （HOMA-IR） was calculated. Results The levels of FINS, HOMA-IR, and Chemerin during the second and the third trimesters of pregnancy in GDM group were statistically significantly higher than those in control group （ P〈0.05 ） . In the two groups, serum Chemerin levels during the second and the third trimesters of pregnancy were positively correlated with FINS and HOMA-IR （P〈 0.05 ）, there was a high correlation in GDM group, while there was a moderate correlation in control group. There were low correlation （ ｜r｜ 〈0.05 ）, no correlation （ ｜r｜ 〈0. 3 ）, and no statistically significant difference （ P〉0. 05 ） between the levels of serum Chemerin during the second and the third trimesters of pregnancy in the two groups and FPG, 1-hour blood glucose after oral glucose, 2-hour blood glucose after oral glucose, and BMI. There was no statistically significant difference in FINS level of pregnant women in GDM group between the second trimester of pregnancy and the third trimester of pregnancy （ P〉0. 05 ）, Chemerin level during the third trimester of pregnancy was statistically significantly higher than that during the second trimester of pregnancy （P〈0.01）, FPG level and HOMA-IR during the third trimester of pregnancy were statistically significantly lower than those during the second trimester of pregnancy （P〈0. 01 ） . In control group, there was no statistically significant difference in the four indexes between t

关 键 词：妊娠期糖尿病 CHEMERIN 胰岛素抵抗 

分 类 号：R714.147[医药卫生—妇产科学]