成人乙型肝炎患者不同转归状态的生命质量效用权重评估  

Evaluation on Life Quality Utility Weight of Hepatitis B Patients with Different Disease Status

作　　者：余倩[1] 范小玲[2] 张曦[1] 金承刚[1] 

机构地区：[1]北京师范大学社会发展与公共政策学院,北京100000 [2]北京地坛医院,北京100000

出　　处：《中国卫生经济》2016年第6期68-70,共3页Chinese Health Economics

基　　金：科技部重大专项(2012ZX10004-904)

摘　　要：目的:测量乙型肝炎不同疾病状态下患者的生命质量效用权重。方法:随机选取北京市地坛医院4种疾病状态下的乙肝患者各60例,采用EQ5D问卷对患者进行问卷调查,并收集患者的性别和年龄。基于日本的人群偏好积分体系,利用多元广义线性模型评估各状态下患者的生命质量效用权重。结果:在校正了年龄和性别因素后,乙肝4个状态下患者的生命质量效用权重值为:慢性乙肝患者的生命质量效用权重值为0.818±0.038,代偿期肝硬化患者的生命质量效用权重值为0.802±0.033,失代偿期肝硬化患者的生命质量效用权重值为0.632±0.053,肝细胞癌患者的生命质量效用权重值为0.406±0.066。结论:患者患病程度越严重,患者的生命质量越差,生命质量效用权重越低。Objective：To evaluate the utility weight of quality of life in hepatitis B patients with different diseases status.Methods：60 cases of Hepatitis B patients with 4 kinds of different diseases states were randomly selected from Beijing Ditan Hospital.EQ5 D questionnaire was used to conduct survey on the patients to collect gender and age of patients. Utility weight of quality of lifewas evaluated by Generalized Linear Model based on Japanese population preference score.Results：Adjusted by patients＇ genderand age, the utility weights of patients with chronic hepatitis B, patients with compensated cirrhosis, patients with decompensated cir-rhosis and patients with hepatocellular carcinoma were 0.818±0.038, 0.802±0.033, 0.632±0.053 and 0.406±0.066, respectively.Conclusion：The more severe the illness degrees of patients were, the lower the life quality and utility weight of patients would be.

关 键 词：乙型肝炎 EQ5D 生命质量效用权重 广义线性模型 

分 类 号：R512.62[医药卫生—内科学]