狗皮膏改工艺后对大鼠佐剂性关节炎的影响  

Effects of Goupi Gao(狗皮膏) after Changing Process on Adjuvant Arthritis in Rats

作　　者：陈霞[1] 刘丹[1] 岳枫[1] 张瀚涛[1] 张智圆[1] 邱琳[1] 刘莹[1] 李晋生[1] 

机构地区：[1]北京同仁堂股份有限公司科学研究所,北京100079

出　　处：《中医药导报》2016年第12期58-61,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：目的:考察狗皮膏不同的提取工艺对大鼠佐剂性关节炎的影响,为狗皮膏工艺改进提供实验依据。方法:采用水提及醇提工艺制备狗皮膏组方提取物。观察提取物对佐剂性关节炎大鼠原发性足跖肿胀、继发性足跖肿胀、胸腺系数、脾脏系数的影响。结果:狗皮膏醇提物和水提物均可显著降低佐剂性关节炎大鼠的原发性足跖肿胀度;狗皮膏水提物可显著降低佐剂性关节炎大鼠继发性足跖肿胀度,明显增加大鼠胸腺系数;各提取物对大鼠脾脏系数没有明显影响。结论:狗皮膏水提工艺对佐剂性关节炎模型大鼠的原发性和继发性足跖肿胀均有显著抑制作用,调节免疫功能可能是其作用机制之一,较醇提工艺具有一定的优势,可作为今后开展狗皮膏工艺改进研究的首选工艺方法。Objective： To discuss the influence of different extraction technology of Goupi Gao （狗皮膏） on adjuvant arthritis in rats, to provide experimental basis for improving Goupi Gao process. Methods： Preparation of Goupi Gao recipe cxtract using water extraction and alcohol extraction. The effects of extract on adjuvant arthritis in rat primary paw swelling, secondary footpad swelling, thymus index, spleen coefficient were observed. Resuits： Alcohol extract and water extract of Goupi Gao significantly decreased the primary degree of foot swelling in rats. Water extract of Goupi Gao significantly reduced the rat secondary footpad swelling degree, and significantly increased the thymus index in rats. The two extract of Goupi Gao had no significant effect on the spleen coefficient in rats. Conclusions： Water extract of Goupi Gao can obviously inhibit the primary and secondary footpad swelling of adjuvant arthritis rats, one of the mechanisms of its may be the immune regulating function. The water extraction process is better than the alcohol extraction process; it is the preferred process method to be used as a future Goupi Gao process improvement research.

关 键 词：狗皮膏 佐剂性关节炎 工艺 醇提 水提 大鼠 

分 类 号：R285.5[医药卫生—中药学]