温肾止泻方敷脐对脾肾阳虚型IBS-D患者5-HT、NO含量的影响  

Influence of Wenshen Zhixie Fang Administrated through Bellybutton on 5-HT and NO of Spleen and Kidney Yang Deficiency Type IBS-D Patients

作　　者：张庆伟[1] 孟浩[1] 唐寅[1] 蔡丽霞[1] 李向[1] 李娜[1] 

机构地区：[1]南京中医药大学附属张家港医院,江苏张家港215600

出　　处：《南京中医药大学学报》2016年第3期217-219,共3页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：江苏省中医药局科技项目(LZ13152);苏州市科技发展技术项目(SYS2011011)

摘　　要：目的观察温肾止泻方敷脐治疗腹泻型肠易激综合征(IBS-D)脾肾阳虚型患者的临床疗效及其对5-HT、NO水平的影响。方法采用电脑随机、平行对照、非盲法试验将患者随机分为2组,试验组58例使用温肾止泻方敷脐配合口服蒙脱石散;对照组59例口服蒙脱石散,治疗10d后评价其疗效差异。结果试验组总有效率为82.76%,优于对照组的66.10%(P<0.05);试验组能明显改善腹痛或不适、大便性状、大便次数等症状(P<0.01),除大便性状外,改善程度均优于对照组(P<0.01);试验组能明显降低血清5-HT含量,升高NO含量,作用优于对照组(P<0.01)。结论温肾止泻方敷脐可以改善脾肾阳虚型IBS-D的临床症状,其作用机制可能是通过调节5-HT、NO水平,减轻肠道敏感性。OBJECTIVE To investigate the effects of Whenshen Zhixie Fang administrated through bellybutton and the influence on 5-HT and NO of spleen and kidney yang deficiency type IBS-D patients.METHODS By using computer,parallel group and non-blinded trials,patients were randomly divided into two groups.58 cases in the treatment group were given Wenshen Zhixie Fang administrated through bellybutton together with orally taken Montmorillonite powder.The control group was given orally taken Montmorillonite powder only.The treating effects were assessed after ten days.RESULTS Total effective rate of the treatment group was 82.76%,which was better than that of the control group（66.10%）（P〈0.05）.Abdominal pain and discomfort were significantly relieved in the treatment group,and the shape of the stool and frequency were also changed for better（P〈0.01）,which were better than those of the control group except the stool.And 5-HT was significantly decreased and NO was increased,which were better than those of the control group（P〈0.01）.CONCLUSION Wenshen Zhixie Fang administered through Bellybutton can improve the clinical symptoms of IBS-D and its mechanism may be related to the regulation of 5-HT and NO levels and reduction of intestinal sensitivity.

关 键 词：温肾止泻方 敷脐 腹泻型肠易激综合征 

分 类 号：R256.3[医药卫生—中医内科学]