戈壁天冬中的木脂素和酚酸类化学成分  

Lignans and Phenolic Compounds fromAsparagus Gobicus

作　　者：马璀[1] 李娟[2,3] 韩怀钦[1] 李南[2] 郑萍[2] 赵荆[4] 李玮琦[5] 姚遥[1,6] 

机构地区：[1]宁夏医科大学基础医学院,宁夏银川750004 [2]宁夏医科大学药学院,宁夏银川750004 [3]宁夏回药现代化工程技术研究中心,宁夏银川750004 [4]华中科技大学同济医学院附属同济医院,湖北武汉430030 [5]中国生物技术发展中心,北京100039 [6]回医药现代化省部共建教育部重点实验室,宁夏银川750004

出　　处：《南京中医药大学学报》2016年第3期291-294,共4页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：宁夏自然科学基金(NZ13077)

摘　　要：目的研究天门冬属植物戈壁天冬中的化学成分。方法使用硅胶柱色谱、凝胶柱色谱、制备液相色谱及薄层色谱等多种色谱分离技术对戈壁天冬全草95%乙醇提取物进行分离纯化,利用理化常数和多种波谱技术对化合物进行了结构鉴定。结果从戈壁天冬中分离鉴定了9个化合物,其中6个是木脂素类化合物,分别为（＋）-松脂素（1）,（-）-丁香脂素（2）,（＋）-丁香脂素-4＇-O-β-D-葡萄糖苷（3）,（-）-表丁香脂素（4）,（＋）-nyasol（5）,（＋）-4＇-O-methylnyasol（6）;3个酚酸类化合物,分别为阿魏酸（7）,异阿魏酸（8）,咖啡酸（9）。结论所有化合物均为首次从本植物中分离得到,其中化合物1-4和8为首次从天门冬属植物中分离得到。OBJECTIVE To study the chemical constituents of Asparagus Gobicus.METHODS Whole herb of Asparagus gobicus were extracted with 95% alcohol.Repeated silica gel column chromatography,Sephadex LH-20 chromatography,preparative HPLC and thin layer chromatography were applied for chemical constituents isolation and purification.Chemical structures of the compounds were elucidated by physical properties and spectra analysis such as NMR and ESI-MS.RESULTS Nine compounds were isolated from the extract of Asparagus gobicus.Six compounds were identified as lignans：（＋）-pinoresinol（1）,（-）-syringaresinol（2）,（＋）-syringaresinol-4＇-O-β-D-glucopyranoside（3）,（-）-episyringaresinol（4）,（＋）-nyasol（5）,（＋）-4＇-O-methylnyasol（6）.Three compounds were phenolic compounds：ferulic acid（7）,isoferulic acid（8）,caffeic acid（9）.CONCLUSION All compounds were isolated for the first time from this plant,and compounds 1~4and 8were obtained from the genus Asparagus for the first time.

关 键 词：戈壁天冬 化学成分 木脂素 酚酸 

分 类 号：R284.2[医药卫生—中药学]