MERS-CoV动物模型研究进展  

Advances in the Animal Models of MERS-CoV

作　　者：蓝佳明[1,2] 邓瑶[1] 谭文杰[1] 

机构地区：[1]中国疾病预防控制中心病毒病预防控制所卫生部医学病毒和病毒病重点实验室,北京102206 [2]河北医科大学病原生物学教研室,石家庄050017

出　　处：《病毒学报》2016年第3期369-375,共7页Chinese Journal of Virology

基　　金：传染病重大专项(2014ZX10004001);国家自然科学基金(81302607);河北省自然科学基金(H2013206108)

摘　　要：中东呼吸综合征冠状病毒(Middle East respiratory syndrome coronavirus,MERS-CoV)最早发现于2012年,是继严重急性呼吸窘迫综合征冠状病毒(severe acute respiratory syndrome coronavirus,SARS-CoV)之后,引起人类严重感染的又一种重要冠状病毒。对于该种新发现、致病性强、病死率高的感染性疾病,开发有效的动物模型对于研究疾病的发病过程、致病机理、评估预防与治疗措施的效果等具有重要理论和现实意义。到目前为止,非人灵长类动物如恒河猴、狨猴,小型动物如小鼠、仓鼠、雪貂、新西兰白兔等均被尝试作为MERS-CoV感染的动物模型。其中一些已经用于评估疫苗或药物的干预效果。本文就MERS-CoV动物模型研究进展作一综述。The Middle East respiratory syndrome coronavirus（MERS-CoV）was first isolated in 2012 from patients that died from severe pneumonia.It was another coronavirus which resulted in severe infection of humans,apart from the severe acute respiratory syndrome coronavirus.The development of an appropriate animal model is necessary to study the pathogenesis and to evaluate the intervening measures against MERS-CoV infection.To date,several small animals（e.g.,mice,Syrian hamsters,and ferrets）have been used to study MERS-CoV infection.In addition,rhesus macaques,common marmosets,and dromedary camels were also utilized as the models for MERS-CoV study.The purpose of this paper is to summarize the advantages and disadvantages of the animal models mentioned above,to provide a thorough understanding of the MERS-CoV study.

关 键 词：中东呼吸综合征冠状病毒 动物模型 非人灵长类动物 小鼠 感染性疾病 

分 类 号：R373.9[医药卫生—病原生物学]