不同组织分化类型与临床分期直肠癌的ADC值研究  

ADC Value Research in Different types of Tissue Differentiation and Clinical Staging for Rectal Cancer

作　　者：朱丽娜[1] 颜社平[2] 卢喜[1] 张峤[1] 赵志伟[1] 明洁[1] 杨爱梅[1] 刘艳[1] 

机构地区：[1]新疆医科大学附属肿瘤医院核磁室,830011 [2]兰州军区乌鲁木齐总医院超声科,830000

出　　处：《临床放射学杂志》2016年第5期746-749,共4页Journal of Clinical Radiology

基　　金：新疆医科大学附属肿瘤医院科研启动基金项目(肿2014-15);新疆医科大学附属肿瘤医院新技术项目

摘　　要：目的探讨表观扩散系数(ADC)在不同组织分化类型与临床分期直肠癌中的应用价值。方法回顾性分析临床确诊的73例直肠癌患者的扩散加权成像(DWI)资料,测量其ADC值。根据术后病理组织分化类型分为6组:高分化(n=11)、高中分化(n=8)、中分化(n=29)、中低分化(n=7)、低分化(n=5)、黏液腺癌(n=13);根据TNM将临床分期分为4期:Ⅰ(n=13)、Ⅱ(n=16)、Ⅲ(n=34)、Ⅳ(n=10),对不同组织分化及临床分期直肠癌ADC值进行统计学分析,P≤0.05为差异有统计学意义。结果不同组织分化类型直肠癌ADC值差异有统计学意义(F=30.993,P=0.000),组间ADC值两两比较:黏液腺癌与其余各组、高与中低、高与低、高中与中低、高中与低、中与低分化组间差异有统计学意义(P<0.05);高与高中、高与中、高中与中、中与中低、中低与低分化组间差异无统计学意义(P>0.05)。黏液腺癌ADC值最高(1480.05±236.05)×10^(-3)mm^2/s,其余各组随着肿瘤分化程度的减低,ADC值有逐渐减低的趋势。不同临床分期直肠癌ADC值差异无统计学意义(F=5.695,P=0.127)。结论直肠癌ADC值可以作为判断肿瘤不同组织分化类型的生物影像指标,但对不同临床分期的判断无帮助。Objective To explore the application value of apparent diffusion coefficient ADC in different types of tissue differentiation and clinical staging of rectal cancer. Methods MRI DWI（ b = 0,1000 s/mm^2） of 73 cases with rectal cancer were analyzed retrospectively,measuring the ADC values. Then they were classified into six groups according to the postoperative pathological differentiation degree： well differentiated（ n = 11）,well-moderately differentiated（ n = 8）,moderately differentiated（ n = 29）,moderately-poorly differentiated（ n = 7）,poorly differentiated（ n = 5）,mucous adenocarcinoma（ n = 13）; According to TNM staging they were classified into four clinical stages： Ⅰ（ n = 13）,Ⅱ（ n = 16）,Ⅲ（ n =34）,Ⅳ（ n = 10）. ADC values in different types of tissue differentiation and clinical staging were statistically analyzed,the difference was statistically significant as P≤0. 05. Results There was a statistically significance among different tissue differentiation types of rectal cancer（ F = 30. 993,P = 0. 000）. The ADC value between mucous adenocarcinoma and other groups,well and moderately poorly,well and poorly,well-moderately and moderately-poorly,well-moderately and poorly,moderately and poorly differentiation were statistically significant（ P 0. 05）; while there was no significant difference has been found between the following groups： well and well-moderately,well and moderately,well-moderately and moderately,moderately and moderately-poorly,moderately-poorly and poorly（ P 0. 05）. The ADC value of mucous adenocarcinoma was the highest（ 1480. 05 ± 236. 05） × 10^-3mm^2/ s,With the tumor differentiation degree decreasing,ADC values decreased gradually in other groups. ADC values showed no statistical significance among different clinical staging of rectal cancer（ F = 5. 695,P = 0. 127）. Conclusion The rectal cancer ADC value can be used as a biological indicator to judge the type of tumor differentiation,but it is not helpful for the judg

关 键 词：直肠癌 表观扩散系数 组织分化类型 临床分期 

分 类 号：R445.2[医药卫生—影像医学与核医学] R735.37[医药卫生—诊断学]