神经生长因子在下腰痛中的研究进展  

Role of nerve growth factor in low back pain

作　　者：魏磊鑫[1] 曹鹏[1] 田野[1] 袁文[1] 

机构地区：[1]第二军医大学附属长征医院骨科,上海200003

出　　处：《中国矫形外科杂志》2016年第11期1015-1018,共4页Orthopedic Journal of China

摘　　要：下腰痛是骨科疾病中的常见症状,是导致残疾的重要原因之一,其临床疗效常不能令人满意。近年来,神经生长因子在慢性疼痛发生发展中的作用已成为研究的热点。目前,已有研究表明神经生长因子在下腰痛的发病过程中有所表达并具有调控疼痛的作用,抑制神经生长因子的表达水平可起到治疗作用。本综述总结了神经生长因子生物活性及其在下腰痛中的作用机制,认为神经生长因子在调控下腰痛疼痛中起重要作用,具有潜在的治疗价值,可以为下腰痛的治疗提供新思路。Low back pain（ LBP）,as a common orthopedic disease symptom,is one of the important reason for the disability. And its clinical treatment often tends to be unsatisfying. In recent years,the role of nerve growth factor（ NGF） in the development process of chronic pain has aroused general interest. At present,researches have indicated that NGF is involved in pathogenesis of LBP and has effects on regulating and controlling its pain. Besides,decreasing the expression level of NGF maybe curative for LBP. This review summarizes the biological activity of NGF and its role in pathogenesis of LBP. Additionally,NGF may have potential therapeutic values and might provide a new idea of treating LBP.

关 键 词：神经生长因子 下腰痛 治疗靶点 

分 类 号：R681.57[医药卫生—骨科学]