血吸虫病高度流行区不同化疗措施的成本-效果分析  

COST-EFFECTIVENESS ANALYSIS FOR DIFFERENT CHEMOTHERAPY INTERVENTION STRATEGIES OF SCHISTOSOMIASIS CONTROL IN HEAVILY ENDEMIC AREAS

作　　者：郭见多[1] 刘兴柱[2] 吴维铎[1] 胡翰亭[3] 张诚[1] 杨卫平[1] 

机构地区：[1]安徽省血吸虫病防治研究所,安徽芜湖241000 [2]山东医科大学 [3]安徽省宿松县血吸虫病防治站

出　　处：《中国寄生虫病防治杂志》2002年第4期234-236,共3页Chinese Journal of Parasitic Disease Control

基　　金：世行贷款中国血吸虫病控制项目 JRMC资助课题(编号 :5- 1 9)

摘　　要：目的　在血吸虫病高度流行区 ,寻找一种既节约经费又能获得较好防治效果的措施。　方法　干预实验的现场为血吸虫病高度流行区的两个行政村。各抽取 5 0 0人以上作为实验组和对照组研究人群 ,分别采取隔年群体化疗与每年群体化疗措施。以基线调查和效果考核资料进行两种干预措施的防治效果及成本效果分析。　结果　干预前后 ,实验组和对照组的人群感染率分别下降了 6 6 .2 6 %和 72 .79% ,各组干预前后的感染率差异有显著性 (P<0 .0 5 ) ,而干预后两组间感染率差异无显著性 (P>0 .0 5 ) ;实验组 (隔年化疗 )两年总的费用消耗为 70 4 2 .5 6元 ,感染率下降 1%的费用为10 6 .2 8元 ,每百人感染率下降 1%的费用为 15 .5 2元 ;对照组两年总的费用消耗为 13173.5元 ,感染率下降 1%的费用为180 .98元 ,每百人感染率下降 1%的费用为 2 6 .2 3元 ,是实验组的 1.5 9倍。　结论　在血吸虫病高度流行区 ,隔年群体化疗措施是一种有效的、成本Objective This study aimed to developing a more cost effective and sustainable chemotherapy scheme in heavily endemic areas of schistosomiasis. Methods Two villages were selected in heavily endemic area of schistosomiasis, each with a sampling more then 500 people as target. Drugs were administered once in two years in one village as trial group and once each year in another village as control group. The intervention were lasted two years. Results The infection rates were reduced 66.26% in trial group and 72.79 % in control group. The reducing of infection rate in each group has significant difference after intervention. But there was no significant difference on the infection rate of schistosoma between two groups after intervention. In the trial group, the total cost was 7 042.56 Yuan (RMB), 106.28 Yuan for 1% reduction of infection rate and 15.52 yuan for 1% reduction of infection rate per 100 persons. In the control group, the costs were 13 175.50, 180.98 Yuan for 1% reduction of infection rate and 26.23 yuan for 1% reduction of infection rate per 100 persons respectively. The cost for 1% reduction of infection rate per 100 persons in control group was 1.59 multiple of the trial group. Conclusion From the view point of cost effectiveness, the strategy of making mass chemotherapy once every two years received similar effect in reducing infection rate but less expensive than drug administration once every year in heavily endemic areas of schistosomiasis.

关 键 词：高度流行区 血吸虫病 群体化疗 成本-效果分析 卫生经济学 

分 类 号：R532.21[医药卫生—内科学]