维药热合美康宫栓质量标准研究  

Stduies on Quality Standard of Rehime Palace Suppository

作　　者：阿迪力.艾斯托拉 阿不都力米提.阿不力提甫 阿卜杜列提普.奥布力 马元甲 穆萨江.麦麦提 罗玉琴[3] 

机构地区：[1]和田地区维吾尔医药研究所,新疆和田848000 [2]和田地区维吾尔医医院,新疆和田848000 [3]中国科学院干旱区植物资源化学重点实验室新疆理化技术研究所,新疆乌鲁木齐830011

出　　处：《亚太传统医药》2016年第11期18-21,共4页Asia-Pacific Traditional Medicine

基　　金：新疆维吾尔自治区科技计划项目(201317103)

摘　　要：目的：建立维药热合美康宫栓的质量标准,控制制剂质量。方法：采用薄层色谱法（TLC）对制剂中黄连和儿茶进行定性鉴别;采用高效液相色谱法对制剂中的盐酸小檗碱进行含量测定。结果：TLC鉴别斑点清晰,分离度好,阴性无干扰;盐酸小檗碱在5.072-30.432μg/mL范围内与峰面积积分线性关系良好,平均回收率为96.96%,RSD为1.70%。结论：该研究建立的方法准确可靠,专属性强,重现性好,可用于热合美康宫栓的质量控制。Objective：to establish a quality standard at the Uyghur medicine ＂ Rahime palace suppository＂,control the quality of the preparation.Methods：For preparation of Coptidisrhizoma and Catechu were qualitatively identified by thin layer chromatography（TLC）;by high performance liquid chromatography（HPLC）of berberine hydrochloride in the preparation was determined.Results：TLC spots were clear and good degree of separation,no negative interference and easy to distinguish;berberine hydrochloride in 5.072-30.432μg/mL range and peak area a good linear relationship.The average recovery rate was96.96%,RSD was 1.70%.Conclusion：This study established the method is accurate and reliable,strong specificity,good reproducibility.It can be used for the quality control of Rahime palace suppository.

关 键 词：热合美康宫栓 质量标准 薄层色谱法 高效液相色谱法 盐酸小檗碱 

分 类 号：R284[医药卫生—中药学]