甲状腺激素联合甲状腺过氧化物酶抗体在产前筛检中的临床意义  

Clinical Significance of Thyroid Hormone Combined with Thyroid Peroxidase Antibody in Prenatal Screening

作　　者：李娜 

机构地区：[1]北京市顺义区妇幼保健院,北京101300

出　　处：《标记免疫分析与临床》2016年第5期509-511,556,共4页Labeled Immunoassays and Clinical Medicine

摘　　要：目的探讨产前筛检中甲状腺激素联合甲状腺过氧化物酶抗体(TPOAb)的临床意义。方法选取我院2014年1月至2015年1月进行产检及分娩的孕妇共420例,检测其FT4、FT3、TSH和TPOAb水平,根据检测结果分为四组:甲功正常、TPOAb阴性(A组),甲功正常、TPOAb阳性(B组),甲功低下、TPOAb阴性(C组)和甲功低下、TPOAb阳性(D组)。对比不同TPOAb及甲功孕妇的甲状腺激素水平、孕周及新生儿一般情况和妊娠并发症发生率。结果 A组和B组的FT3、FT4和TSH水平无显著差异(P<0.05);C组、D组的FT3、FT4显著低于A组、B组,TSH显著高于A组、B组(P<0.05);D组的FT3、FT4显著低于C组,TSH显著高于C组(P<0.05)。A组和B组的孕周及新生儿一般情况无显著差异(P<0.05);C组、D组的新生儿胸围显著低于A组、B组,新生儿体重和新生儿头围显著高于A组、B组(P<0.05);D组的新生儿胸围显著低于C组,新生儿体重和新生儿头围显著高于C组(P<0.05)。B组、C组的胎儿宫内发育迟缓率显著高于A组(P<0.05),其他并发症在各组之间无显著差异(P>0.05)。结论甲状腺激素联合TPOAb和产科并发症具有一定相关性,孕期筛查并及时治疗有助于改善妊娠结局和胎儿预后。Objective To investigate the clinical significance of thyroid hormone combined with thyroid peroxidase antibody（TPOAb） in prenatal screening.Methods The serum thyroid hormone and TPOAb levels in 420 pregnant women were detected.According to test results,they were divided into four groups：normal thyroid function with TPOAb negative（group A）,normal thyroid function with TPOAb positive（group B）,lowthyroid function with TPOAb negative（group C） and thyroid function is lowwith TPOAb positive（group D）.The thyroid hormone levels,gestational age and neonatal general conditions,and the incidence of pregnancy complications were compared.Results There was no significant difference on FT3,FT4 and TSH levels between group A and group B（P〈0.05）.The serum FT3 and FT4in group C and group D were significantly lower than those in group A and group B,and TSH level was significantly higher than that in group A and group B（P〈0.05）.The serum FT3 and FT4in group D was significantly lower than group C,and TSH was significantly higher than in group C（P〈0.05）.There was no significant difference in gestational age and newborn general condition between Group A and group B（P〈0.05）.The newborn bust in group C and group D was significantly lower than group A and group B,and neonatal birth weight and head circumference were significantly higher in group A and group B（P〈0.05）.The newborn bust in group D was significantly lower than group C,the lowbirth weight and neonatal head circumference was significantly higher than in group C（P〈0.05）.The intrauterine growth retardation rate in group B and group C was significantly higher than group A（P〈0.05）,other complications was no significant difference（P〈0.05）.Conclusion Thyroid hormone combine with TPOAb have some relevance with obstetric complications.The pregnancy screening and timely treatment could improve pregnancy and fetal outcome.

关 键 词：产前筛检 甲状腺激素 甲状腺过氧化物酶抗体 

分 类 号：R714.256[医药卫生—妇产科学]