空腹血糖异常切点下调对北京地区中老年男性糖调节受损患病情况的影响研究  

Impact of Lowering Cut-Point of Impaired Fasting Glucose in Prevalence Proportions of Impaired Glucose Regulation in Middle-aged and Elderly Male Patients in Beijing

作　　者：康怡[1] 徐洪涛[1] 张宝和[1] 田光[1] 赵宏[1] 姚合斌[1] 胡晓东[1] 杜凯音[1] 华伟[1] 黄火高[1] 王吉[1] 连世杰 

机构地区：[1]海军总医院,北京100048

出　　处：《标记免疫分析与临床》2016年第5期546-550,共5页Labeled Immunoassays and Clinical Medicine

基　　金：海军后勤科研项目(CHJ12L024)

摘　　要：目的应用北京地区中老年男性体检资料研究空腹血糖异常切点下调对糖调节受损(IGR)诊断和防控的影响。方法选取北京地区中老年男性共计864人,行75g口服葡萄糖耐量(OGTT)试验,根据ADA2003年标准分为四组:糖耐量正常组317(NGT)、单纯空腹血糖受损(I-IFG)325例、单纯糖耐量减低(I-IGT)126例和空腹血糖受损合并糖耐量减低(IFG/IGT)96例,其中IFG组根据5.6mmol/L为界值分为IFG1和IFG2两组,分析空腹血糖异常切点下调对糖调节受损各组分构成比的影响,评估合并代谢综合征相关疾病的差异。结果 1按照WHO1999和ADA2003标准诊断的糖调节受损人群构成比有显著差异:NGT组56.02%vs 36.69%,I-IFG组18.29%vs 37.62%,I-IGT组19.68%vs 14.58%,IFG/IGT 6.02%vs 11.11%;2随着糖代谢紊乱程度的逐渐加重,代谢综合征各组分的异常比例逐渐升高:3两种诊断标准下糖调节受损人群合并体重指数(F=14.02,P<0.01)、腰围(F=14.70,P<0.01)和甘油三酯(F=6.00,P=0.01)异常的组间比较有显著性差异。结论与WHO1999年诊断标准相比,ADA2003标准明显扩大IFG和IFG/IGT人群比例,新增诊断人群合并多种代谢紊乱的比例明显增加,从糖耐量异常早期防控角度,诊断切点下移有一定的合理性。Objective To investigate the impact of lowering cut-point of impaired fasting glucose in diagnosis,prevention and control of impaired glucose regulation in middle-aged and elderly male patients in Beijing.Methods Assessed by oral glucose tolerance test（OGTT）,according to ADA2003 diagnostic criteria,864middle-aged and elderly male cadres in Beijing were took oral glucose tolerance test,and then divided into normal glucose tolerance（NGT,n = 317）,isolated impaired fasting glycemia（I-IFG,n = 324）,isolated impaired glucose tolerance（I-IGT,n = 126）,combined IFG / IGT（n = 96） groups based on ADA2003 diagnostic criteria.M oreover,according cut-point of 5.6mmol / L,I-IFG group were divided again into IFG1 and IFG2.The impact of lowering cut-point of IFG in prevalence proportions of IGR was analyzed.The difference of combined with metabolic syndrome related diseases were evaluated.Results 1 According to WHO1999 and ADA2003 diagnosis criteria,there were significant differences of prevalence proportions between subgroups of impaired glucose regulation：56.02% vs 36.69% for NGT group,18.29% vs 37.62%for I-IFG group,19.68% vs 14.58% for I-IGT group,and 6.02% vs 11.11% for IFG / IGT.With the deterioration of glucose regulation,the proportion of metabolic syndrome components disease increased gradually.In the light of two diagnosis criteria,the ratio of impaired glucose regulation combined with metabolic abnormal differentiated significantly,body mass index（F = 14.02,P〈0.01）,waist circumference（F =14.70,P〈0.01）,and triglycerides（F = 6.00,P = 0.01）.Conclusion Compared with WHO1999 diagnostic criteria,ADA2003 standard significantly expanded proportion of the IFG and IFG / IGT patients.The proportion of newdiagnostic patients combined with metabolic disorders increased significantly.From the point of early prevention and control of the disease,the down-regulated IFG cut-point has its rationality.

关 键 词：糖调节受损 空腹血糖异常 诊断切点 代谢综合征 

分 类 号：R587.1[医药卫生—内分泌]