沉默信息调节因子1对脂类代谢的调控作用  

Regulation of Silent Information Regulator 1 on Lipid Metabolism

作　　者：吴铁梅[1] 闫素梅[1] 格日乐玛 

机构地区：[1]内蒙古农业大学动物科学学院,呼和浩特010018

出　　处：《动物营养学报》2016年第5期1285-1293,共9页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：国家公益性行业(农业)科研专项经费(201003061)

摘　　要：沉默信息调节因子1(SIRT1)通过脱乙酰作用能抑制脂肪生成相关基因过氧化物酶体增殖物激活受体γ(PPARγ)和固醇调节元件结合蛋白1c(SREBP1c)的转录活性,从而抑制脂肪细胞分化,降低脂肪沉积,促进脂肪动员。SIRT1通过调节脂类代谢相关的信号通路SIRT1-腺苷酸活化蛋白激酶(AMPK)和SIRT1-哺乳动物雷帕霉素靶蛋白(m TOR)减少脂肪合成,加快脂肪分解,降低脂肪的沉积量。本文主要综述了SRIT1通过相关转录因子与信号通路对动物脂类代谢的调节作用,为进一步研究动物的脂类代谢及改善肉品质提供依据。Silent information regulator 1（SIRT1） can inhibit the transcription activity of lipogenic-related genes peroxisome proliferator-activated receptors gamma（PPARγ） and sterol regulatory element binding factor1 c（SREBP1c） through the deacetylation,resulting in inhibiting anabolism of lipid and promoting catabolism.In addition,SIRT1 reduces lipid anabolism,accelerates lipolysis and reduces fat deposition,which may be associated with regulating the SIRT1-adenosine 5＇-monophosphate-activated protein kinase（AMPK） and SIRT1-mammalian target of rapamycin（mTOR） signaling pathways.This reviewsummarizes the regulation of SIRT1 on animal lipid metabolism via related transcription factors and signaling pathways,which provides the basis for the further investigation of animal lipid metabolism and improving meat quality.

关 键 词：沉默信息调节因子1 脂类代谢 转录因子 信号通路 

分 类 号：S811.2[农业科学—畜牧学]