低分子肝素对慢性肺源性心脏病失代偿期血清D-二聚体、凝血因子Ⅷ的影响  

Effect of Low Molecular Weight Heparin on Serum D-dimer and Coagulation Factor of Chronic Pulmonary Heart Disease

作　　者：朱宝山[1] 王永[1] 范远威[1] 陈如健 

机构地区：[1]江苏省新沂市铁路医院呼吸内科,中国新沂221400

出　　处：《国际老年医学杂志》2016年第3期120-123,共4页International Journal of Geriatrics

摘　　要：目的：探讨低分子肝素（LMH）抗凝治疗对慢性肺源性心脏病失代偿期（LCPCPHD）血清D-二聚体（D-D）、凝血因子Ⅷ相关抗原（ⅧR：Ag）及凝血因子Ⅷ（Ⅷ：C）的影响.方法：将70例LCPCPHD患者按就诊顺序1：1比例随机分成观察组和对照组,各35例,两组患者均给予常规综合治疗,包括：吸氧、解痉平喘、止咳化痰、抗感染,活血化瘀及扩血管等治疗,观察组在此基础上加用LMH 5000 u,1次/d.两组均以10d为一个疗程.观察两组D-D、ⅧR：Ag和Ⅷ：C治疗前后变化.结果：①观察组总有效率为91.4％ （32/35）,对照组总有效率为74.3％ （26/35）,两组比较差异有统计学意义（P＜0.05）;②两组治疗后血清D-D、ⅧR：Ag及Ⅷ：C浓度均明显下降,观察组下降更明显,与对照组相比差异均有统计学意义（P＜0.01）;③观察组治疗后血清D-D、ⅧR：Ag及Ⅷ：C浓度均明显下降,与治疗前对比差异均有统计学意义（P＜0.01）.结论：使用LMH抗凝治疗LCPCPHD可降低血液的高凝状态,提高疗效.OBJECTIVE： To explore the influence of low molecular heparin （LMH） anticoagulant therapy on serum D - dimer （D- D）, factor Ⅷ related antigen （Ⅷ R： Ag） and factor Ⅷ （Ⅷ： C ） chronic pulmonary heart disease loss compensatory stage （LCPCPHD）. METHODS： 70 patients with LCPCPHD according to 1：1 ratio of the visiting sequence were randomly divided into observation group （n = 35 ） and control group （n = 35 ）. The two groups were given conventional treatment, including oxygen, spas- molysis, relieving cough and phlegm, antiinfection, activating blood circulation to remove stasis and vasodilator therapy. And obser- vation group used LMH based in the therapy above （5000U, 1 times daily）. In the two groups 10 days were as a course of treatment. The changes of D - D, ⅧR： Ag andⅧ： C before and after treatment in the two groups were observed. RESULTS： ①The total ef- fective rate in the observation group was 91.4% （32/35） and 74. 3% （26/35） in the control group. There was statistically signifi- cant difference in the two groups （P 〈 0. 05 ） ; ②After the treatment in the two groups serum D -D, ⅧR： Ag and Ⅷ： C concentra- tions were significantly decreased, the ones in observation group decreased more significantly. There were statistically significant differences （P 〈 0.01 ） ; ③In the observation group after treatment, serum D -D,ⅧR： Ag and Ⅷ： C concentrations were signifi- cantly decreased compared with the ones before treatment. There were statistically significant differences （ P 〈 0.01 ）. CONCLU- SION： LCPCPHD can reduce the high blood coagulation state and improve the curative effect by using LMH.

关 键 词：低分子肝素 慢性肺源性心脏病 D-二聚体 凝血因子Ⅷ相关抗原 凝血因子Ⅷ 

分 类 号：R544.1[医药卫生—心血管疾病]