Mex3B： a coreceptor to present dsRNA to TLR3  

作　　者：Shu Zhu, Geng Wang, Xuqiu Lei Richard A Flavell 

出　　处：《Cell Research》2016年第4期391-392,共2页细胞研究（英文版）

摘　　要：Toll-Like Receptors （TLRs） play critical roles in the early innate im- mune response to invading pathogens by sensing microorganisms; a num- ber of accessory molecules have been shown to assist microbial recognition by TLRs. In a recent paper in Cell Research, Yang et ai. demonstrate that Mex3B is associated with TLR3 in the endosomes and promotes dsRNA binding and proteolytic processing of TLR3, suggesting that Mex3B acts as a coreceptor of TLR3 in response to dsRNA.

关 键 词：DSRNA Toll样受体 微生物入侵 双链RNA 通过检测 水解处理 病原体 TLR 

分 类 号：Q257[生物学—细胞生物学] S852.659.4[农业科学—基础兽医学]