左室射血分数与老年慢性心力衰竭患者认知功能的关系  

The relationship between left ventricular ejection fraction and cognitive function in elderly patients with chronic heart failure

作　　者：臧鸿斌[1] 李晓东[1] 

机构地区：[1]中国医科大学附属盛京医院心内科,辽宁省沈阳市110001

出　　处：《中国心血管病研究》2016年第5期444-447,共4页Chinese Journal of Cardiovascular Research

摘　　要：目的探索左室射血分数与老年慢性心力衰竭患者认知功能的关系。方法人选左室射血分数〈45％且年龄≥60岁的住院慢性心衰患者共222例。使用简易智能量表（MMSE）进行认知功能评估，收集相关临床资料，采用Logistic回归分析校正混杂因素的影响。结果以MMSE评分〈24分作为认知功能障碍的界值，46．4％（103／222）的患者存在认知功能障碍。多因素分析结果显示，在以年龄、受教育情况、长期饮酒史、伴发糖尿病史校正后，左心室射血分数减低可以增加心衰患者认知功能障碍的风险（DR=O．92，95％CIO．87～0．97）。结论慢性心衰患者认知障碍发生率较高。左室射血分数减低是慢性心衰患者发生认知功能障碍的独立危险因素。Objective To explore the relationship between left ventricular ejection fraction （LVEF） and cognitive function in elderly patients with chronic heart failure. Methods Using Mini-Mental State Examination （MMSE） to evaluate the cognition function of 222 chronic heart failure patients with age ~ 60 years and LVEF〈 45%. Results Based on the MMSE scores, 103 patients suffered from cognitive impairment （scores〈24）. Mufti- factorial analysis showed that after controlling by age, schooling, long-term drinking and concomitant diabetes mel- litus, lower LVEF was a risk factor for cognitive impairment in patients with chronic heart failure （0R=0.92,95% Cl 0.87-0.97 ）. Conclusion Incidence of cognitive impairment is high in hospitalized patients with chronic heart failure. Lower LVEF is an independent risk factor for cognitive impairment in patients with chronic heart failure.

关 键 词：慢性心功能衰竭 认知功能障碍 简易智能量表 左室射血分数 

分 类 号：R541.6[医药卫生—心血管疾病]