慢性自发性荨麻疹血小板参数及P选择素的检测  

Detection of the levels of platelet parameters and soluble P- selectin in the patients with chronic spontaneous urticaria

作　　者：马一平[1] 李诚让[1] 吴建兵[1] 崔盘根[1] 林麟[1] 

机构地区：[1]中国医学科学院皮肤病研究所,南京210042

出　　处：《中国麻风皮肤病杂志》2016年第5期275-277,共3页China Journal of Leprosy and Skin Diseases

摘　　要：目的:检测慢性自发性荨麻疹(CSU)患者血小板参数及P选择素的表达水平,并分析与疾病严重程度的相关性。方法:对120例CSU患者和40名健康对照者进行血小板相关参数和可溶性P选择素检测,并分析与自身免疫血清实验(ASST)结果、CSU疾病严重度评分(USS)的相关性。结果:CSU组平均血小板体积(MPV)、血小板分布宽度(PDW)和可溶性P选择素水平分别为(11.23±1.36)f L、(13.41±2.26)f L和(74.16±20.32)ng/m L,明显高于正常对照组的(9.38±1.24)f L,(11.17±2.51)f L和(32.14±8.37)ng/m L。CSU组血小板计数为(176.16±41.05)×109/L,明显低于健康对照组的(227.35±42.33)×109/L。所有患者中USS评分与P选择素呈正相关,ASST阳性患者中USS与MPV呈正相关。结论:CSU组MPV、PDW和可溶性P选择素值升高,且与疾病严重程度相关,提示CSU患者中存在血小板活化。Objective： To detect the levels of platelet parameters and soluble P- selectin in the patients with chronic spontaneous urticaria（ CSU）. Methods： The levels of platelet parameters,and soluble P- selectin in120 patients and 40 healthy controls were detected and the relationship between these parameters and autoimmune serum test（ ASST） and urticaria severity score（ USS） was analyzed. Results： The levels of mean platelet volume（ MPV）,platelet distribution width（ PDW） and soluble P- selectin were（ 11. 23 ± 1. 36） f L,（ 13. 41 ±2. 26） f L and（ 74. 16 ± 20. 32） ng / m L in the patients,which were significantly higher than those in controls group（ 9. 38 ± 1. 24 f L,11. 17 ± 2. 51 f L and 32. 14 ± 8. 37 ng / m L,respectively）. The level of platelet count in CSU group was（ 176. 16 ± 41. 05） × 109/ L,which was significantly lower than that in controls（ 227. 35 ± 42.33） × 109/ L. There was a significant positive correlation between USS and P- selectin levels in the patients and the correlation between USS and MPV in the patients with positive ASST was also significantly positive.Conclusion： The levels of MPV,PDW and soluble P- selectin were increased in the patients with CSU and were correlated to the disease severity. The platelets are activated in the patients with CSU.

关 键 词：荨麻疹 平均血小板体积 P选择素 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]