珂立苏、西地那非联合机械通气治疗重度新生儿持续肺动脉高压的临床观察  

Clinical Observation of Calsurf and Sildenafil Combined with Mechanical Ventilation in the Treatment of Severe Persistent Pulmonary Hypertension of the Newborn

作　　者：李正浩[1] 郭洁[1] 刘国志[1] 马长永[2] 郑杰[1] 

机构地区：[1]潍坊市益都中心医院新生儿科,山东青州262500 [2]第四军医大学社科部,陕西西安710032

出　　处：《医学与哲学（B）》2016年第4期26-28,共3页Medicine & Philosophy(B)

摘　　要：探讨珂立苏、西地那非联合机械通气治疗重度新生儿持续肺动脉高压临床效果。本研究将47例重度新生儿持续肺动脉高压患儿随机分为观察组和对照组,对照组给予西地那非、常频机械通气等常规治疗,观察组再加用珂立苏治疗,比较两组治疗前后的临床指标和有效率。结果表明,两组肺动脉收缩压、动脉血氧分压、动脉血二氧化碳分压和氧合指数与治疗前相比有统计学意义(P<0.05),且观察组改善显著,与对照组相比差异有统计学意义(P<0.05);观察组有效率91.67%,对照组有效率73.91%。因此,珂立苏、西地那非联合机械通气治疗重度新生儿持续肺动脉高压效果更显著。To investigate the effect of catsurf and sildenafil combined with mechanical ventilation in the treatment of severe persistent pulmonary hypertension of the newborn （PPHN）. In this study, forty seven newborns with severe persistent pulmonary hypertension were randomly divided into observation group and control group. Controt group received routine therapy including sildenafil and mechanical ventilation, while control group received calsurf besides above therapy, and they were compared with clinical index and effective rate in pretherapy and post-treatment. The results showed that there were significant differences in clinical indexes such as pulmonary artery systolic pressure, arterial oxygen tension, arterial carbon dioxide tension and oxygenation index in the two groups after the treatment compared with that of before then treatment. But there were significant differences in observation group （P〈0.05）. In observation group, the effective rate was 91.67M, while the effective rate was 73.9% in control group. Therefore, there were more significant results in calsurf and sildenafil combined with mechanical ventilation in the treatment of severe PPHN.

关 键 词：珂立苏 西地那非 机械通气 新生儿 重度持续肺动脉高压 

分 类 号：R722.19[医药卫生—儿科] R544.16[医药卫生—临床医学]