血浆NT-proBNP浓度与未治疗高血压严重程度的相关性研究  

The correlation study between plasma NT-proBNP concentration and severity of untreated hypertension

作　　者：田可港 孙玉娟 聂亚红 牟晓峰 张磊 张蓉 

机构地区：[1]青岛市中心医院检验科,山东青岛266042

出　　处：《医学检验与临床》2016年第2期4-6,25,共4页Medical Laboratory Science and Clinics

基　　金：青岛市卫生局立项课题,2011-WSZD075.

摘　　要：目的：评估血浆NT-proBNP水平与高血压严重程度的关系。方法：在134例未经治疗及未发生心衰的原发性高血压患者中检测血浆NT-proBNP浓度和临床各指标之间的关系（平均年龄57.0±10.6，平均血压：160.4±14.2/97.1±9.2 mmHg；平均NT-proBNP浓度为221.1±228.1pg/ml）。依据NT-proBNP浓度将患者分为两组，正常组：〈125pg/ml，平均浓度为65.5±38.5, n=59）；增高组（〉125pg/ml,平均浓度为347.5±273.1, n=75）。分别检测两组的多项临床指标。结果：增高组与正常组相比有更高的心电图电压指数（SV1＋RV5：3.49±1.12VS 2.96±0.83 mV ,P=0.0031）；更高的心胸比（CTR）（47.1±4.8VS 44.9±4.5%,P=0.0039）；更高的左心室质量指数（LVMI）（120±30VS 101±24g/m^2,P=0.0005）；更高的减速时间（DT）（221±35 VS 188±26 ms,P=0.0001）；此外还有更小的E波/V波比值（0.78±0.21VS 0.94±0.26,P=0.0002）。两组的血压和BMI无明显的差异。运用多重线性回归分析方法，发现肾素和DT与NT-proBNP相关。结论：NT-proBNP可能是早期原发性高血压患者的一个指示因子。Objective：To discuss the relationship between plamsa NT-proBNP and the severity of untreated hypertension. Methods：The relationship between the plasma NT-proBNP level and various clinical parameters was examined in 134 untreated hypertensive patients without heart failure or atrial fibrillation （mean age： 57.0±10.6; mean blood pressure： 160.4±14.2 /97.1±9.2mmHg; mean NT-proBNP： 221.1±228.1 pg/ml）. The patients were divided into 2 groups based on NT-proBNP： normal （〈125pg/ml, mean 65.5±38.5, n=59）; or elevated （〉125pg/ml, mean 347.5±273.1, n=75）.Results： The elevated NT-proBNP group had a significantly greater electrocardiographic voltage index （SV 1 ＋RV 5 ;3.49±1.12VS 2.96±0.83 mV ,P=0.0031）, cardiothoracic ratio/chest radiography （CTR; 47.1±4.8VS 44.9±4.5%,P=0.0039）, left ventricular mass index （LVMI; 120±30VS 101±24g/m^2,P=0.0005 ） and deceleration time （DT; 221±35 VS 188±26 ms,P=0.0001）, as well as a smaller E-wave to A-wave （E/A ratio） （0.78±0.21VS 0.94±0.26,P=0.0002）, compared with the normal NT-proBNPgroup. There were no significant differences in casual blood pressure and body mass index between the 2 groups. Using multiple regression analysis, renin and DT were significantly associated with NT-proBNP.Conclusions： Results suggest that NT-proBNP is a useful indicator for the initial assessment of the severity of essential hypertension.

关 键 词：NT-PROBNP 高血压 LVMI 

分 类 号：R544.1[医药卫生—心血管疾病]