Enantioselective synthesis of 10-allylanthrones via iridium-catalyzed allylic substitution reaction  

作　　者：Zheng-Le Zhao Qing Gu Xin-Yan Wu Shu-Li You 

机构地区：[1]Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, China [2]State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

出　　处：《Chinese Chemical Letters》2016年第5期619-622,共4页中国化学快报（英文版）

基　　金：the National Basic Research Program of China (973 Program, No. 2015CB856600);National Natural Science Foundation of China (Nos.21572252, 21332009, 21421091) for generous financial support

摘　　要：A highly enantioselective allylic substitution reaction of anthrones with aromatic or aliphatic allyl carbonates was realized by using iridium catalyst prepared from [Ir（COD）CI]2 and BHPphos. Substituted 10-allylanthrones were obtained in excellent yields and with excellent enantioselectivity and regioselectivity （up to 98% yield, 99700 ee） under mild conditions.A highly enantioselective allylic substitution reaction of anthrones with aromatic or aliphatic allyl carbonates was realized by using iridium catalyst prepared from [Ir（COD）CI]2 and BHPphos. Substituted 10-allylanthrones were obtained in excellent yields and with excellent enantioselectivity and regioselectivity （up to 98% yield, 99700 ee） under mild conditions.

关 键 词：Allylic substitution Anthrone Asymmetric catalysis Enantioselectivity Iridium 

分 类 号：O621.3[理学—有机化学]