Metal complexes of anthranilic acid derivatives: A new class of noncompetitive α-glucosidase inhibitors  

作　　者：Jing-wei Zheng Lin Ma 

机构地区：[1]School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China

出　　处：《Chinese Chemical Letters》2016年第5期627-630,共4页中国化学快报（英文版）

摘　　要：Metal complexes of anthranilic acid derivatives that constitute a novel class of non-sugar-type α- glucosidase inhibitors were synthesized and assessed in vitro for inhibitory activity. All of the AgO） complexes （9-16） inhibited α-glucosidase at the nanomolar scale, while 3,5-dichloroanthranilic acid silver（1） （9） was the most potent （ICso = 3.21 nmol/L）. Analysis of the kinetics of enzyme inhibition indicated that the mechanism of the newly prepared silver complexes was noncompetitive. The structure-activity relationships were also analyzed, and thev are discussed in this report.Metal complexes of anthranilic acid derivatives that constitute a novel class of non-sugar-type α- glucosidase inhibitors were synthesized and assessed in vitro for inhibitory activity. All of the AgO） complexes （9-16） inhibited α-glucosidase at the nanomolar scale, while 3,5-dichloroanthranilic acid silver（1） （9） was the most potent （ICso = 3.21 nmol/L）. Analysis of the kinetics of enzyme inhibition indicated that the mechanism of the newly prepared silver complexes was noncompetitive. The structure-activity relationships were also analyzed, and thev are discussed in this report.

关 键 词：α-Glucosidase Anthranilic acid derivatives Metal complexes Noncompetitive inhibitors 

分 类 号：O641.4[理学—物理化学]