NT-proBNP在小儿病毒性心肌炎诊断和心功能评估中的应用  

Application of precursor of B- type natriuretic peptide for the diagnosis of viral myocarditis and assessment of heart function in children

作　　者：李舟文[1] 

机构地区：[1]嘉应学院医学院临床技能中心诊断学教学组,广东梅州514031

出　　处：《分子诊断与治疗杂志》2016年第3期178-181,共4页Journal of Molecular Diagnostics and Therapy

摘　　要：目的检测血浆B型钠尿肽前体(precursor of B-type natriuretic peptide,NT-proBNP)在小儿病毒性心肌炎患者中的浓度水平,探讨将其作为评价小儿病毒性心肌炎诊断及心功能状态的价值。方法门诊及住院病毒性心肌炎患儿68例,对照组109例。运用电化学发光免疫技术测定NT-proBNP浓度,超声心动图检测左心室射血分数(left ventricular ejection fravtion,LVEF)及左室缩短分数(left ventricular fraction of shortening,LVFS),根据改良ROSS评分对患儿心肌炎进行心功能分级。结果病毒性心肌炎组NT-proBNP水平(2 870±492 pg/m L)明显高于对照组(156±45 pg/m L),两组之间差异有统计学意义(P<0.01),血浆NT-proBNP水平与LVFS、LVEF呈负相关,血浆NT-proBNP水平与心衰严重程度呈正相关。结论血浆NT-proBNP水平可以反映病毒性心肌炎患儿左室功能不全的情况,可协助病毒性心肌炎的诊断,可用于该类患儿心功能的评估。Objective To discuss the value of the precursor of B-type natriuretic peptide（NT-proBNP）for assessment of viral myocarditis and heart function in children. Methods The plasma NT-proBNP level was measured by electrochemiluminescence and both of the left ventricular ejection fraction（LVEF） and the left ventricular（LVFS） were assessed by echocardiography in 68 children with viral myocarditis and 109 heathly children. The patients were provided cardiac function grading according to the modified ROSS score. Results There were significant differences among viral myocarditis cases and healthy cases. The level of NT-proBNP in the former（2 870±492 pg/m L）was higher than in the later（156±45 pg/m L）.Plasma NT-proBNP level was negatively correlated with the level of LVFS and LVEF,while it was positively correlated with the severity of cardiac function. Conclusion The level of plasma NT-proBNP could reflect the left ventricular dysfunction in viral myocarditis children,and it may be used in diagnosing the viral myocarditis and assessing ventricular dysfunction.

关 键 词：B型钠尿肽前体 小儿病毒性心肌炎 诊断 心功能评估 

分 类 号：R725.4[医药卫生—儿科]